GC-FID/MS法测定胆胰康泰散的组成及3种成分的含量  

Determination of composition and contents of 3 components in Danyi Kangtai powder by GC-FID/MS

作　　者：潘红[1] 郑博 黄一鹤 赵旻[2] 王淼[2] 赵春杰[2] PAN Hong;ZHENG Bo;HUANG Yihe;ZHAO Min;WANG Miao;ZHAO Chunjie(The Hospital of Shandong Technology and Business University,Yantai 264005,China;School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China;College of Chemistry,Liaoning University,Shenyang 110036,China)

机构地区：[1]山东工商学院医院,山东烟台264005 [2]沈阳药科大学药学院,辽宁沈阳110016 [3]辽宁大学化学院,辽宁沈阳110036

出　　处：《沈阳药科大学学报》2018年第11期961-967,共7页Journal of Shenyang Pharmaceutical University

摘　　要：目的分析胆胰康泰散挥发油组成并建立同时测定胆胰康泰散中柠檬烯、α-香附酮、棕榈酸3种成分含量的方法。方法采用GC-MS法确定胆胰康泰散挥发油中主要成分组成,应用GC-FID法测定胆胰康泰散中柠檬烯、α-香附酮、棕榈酸的含量。结果 GC-MS法测得胆胰康泰散挥发油中38种成分,GC-FID法测得胆胰康泰散中含柠檬烯、α-香附酮、棕榈酸的线性分别为0. 187~5. 984、0. 503~16. 080、0. 273~8. 736 g·L-1,相关系数分别为0. 999 5、0. 999 9、0. 999 8;平均回收率分别为100. 8%、102. 9%、97. 7%,RSD分别为1. 9%、1. 8%、1. 6%(n=9)。结论鉴定了胆胰康泰散主要成分组成,首次建立了胆胰康泰散中3种成分的含量测定方法,可为胆胰康泰散的质量控制提供依据。Objective To analyze the composition of volatile oil of Danyi Kangtai powder and establish a simultaneous determination method to determine the contents of limonene,α-cyperone and palmitic acid in Danyi Kangtai powder. Methods The main components of volatile oil of Danyi Kangtai powder were determined by GC-MS,and the contents of limonene,α-cyperone and palmitic acid were determined by GCFID. Results The linear range of limonene,α-cyperone and palmitic acid was 0. 187-5. 984,0. 503-16. 080,0. 273-8. 736 g·L-1 respectively,and the correlation coefficients were 0. 999 5,0. 999 9 and 0. 999 8,respectively; The average recovery was 100. 8%,102. 9%,97. 7%,respectively,and RSD was 1. 9%,1. 8% and 1. 6%（ n = 9）. Conclusion The main components of Danyi Kangtai powder are identified,and the content determination method of the three components in Danyi Kangtai powder is established for the first time,which can provide the basis for quality control of Danyi Kangtai powder.

关 键 词：胆胰康泰散 气相-质谱联用 气相色谱法 挥发油 含量测定 

分 类 号：R917[医药卫生—药物分析学]