血清Ox-LDL、hs-CRP、cTnⅠ在冠心病患者中的表达水平及意义  

Significance of Levels of Serum Ox-LDL,hs-CRP and cTnⅠ in Patients with Coronary Heart Disease

作　　者：鲍巧玲 BAO Qiaoling(The Third Department of Coronary Heart Disease,Qinghai Cardiovascularand Cerebrovascular Disease Hospital,Xining 810000,China)

机构地区：[1]青海心脑血管病专科医院冠心病三科,西宁810000

出　　处：《解放军预防医学杂志》2018年第11期1389-1391,1394,共4页Journal of Preventive Medicine of Chinese People's Liberation Army

摘　　要：目的探讨血清氧化修饰型低密度脂蛋白(Ox-LDL)、超敏C反应蛋白(hs-CRP)、肌钙蛋白I(c TnⅠ)在冠心病患者中的表达水平及意义。方法选取2015年1月-2017年12月在我院治疗的冠心病患者145例,其中不稳定心绞痛(UAP)患者52例,稳定型心绞痛(SAP)患者49例,急性心肌梗死(AMI)患者44例,同时选取健康志愿者50名作为对照组,检测各组血清Ox-LDL、hs-CRP和c TnⅠ水平。结果 AMI组、UAP组和SAP组血清Ox-LDL、hs-CRP和c TnⅠ明显高于对照组(P<0.05),其中AMI组血清Ox-LDL、hs-CRP和c TnⅠ分别为(33.18±5.40) g/ml、(16.82±3.02) mmol/L和(3.62±0.56) mmol/L,明显高于UAP组和SAP组(P<0.05);重度狭窄患者血清Ox-LDL、hs-CRP和c TnⅠ分别为(37.18±5.68) g/ml、(17.80±3.15) mmol/L和(4.02±0.89) mmol/L,明显高于轻度和中度狭窄患者(P<0.05); Ox-LDL、hs-CRP和c TnⅠ与Gensini评分呈正相关(r=0.462、0.414和0.428,P<0.05)。结论冠心病患者血清Ox-LDL、hs-CRP和c TnⅠ明显升高,与患者冠心病类型及冠脉狭窄程度有关。Objective To investigate the levels and significance of serum oxidized low density lipoprotein （Ox-LDL）,hypersensitive C-reactive protein （hs-CRP） and troponin I （cTnⅠ） in patients with coronary heart disease. Methods BetweenJanuary 2015 and 2017, 145 patients with coronary heart disease treated in our hospital were selected, including 52 patients withunstable angina pectoris （UAP）, 49 patients with stable angina pectoris （SAP）, and 44 patients with acute myocardial infarction（AMI）, while another 50 healthy volunteers were selected as the control group. The serum levels of Ox-LDL, hs-CRP and cTnⅠ were detected. Results The serum levels of Ox-LDL, hs-CRP and cTn Ⅰin AMI group, UAP group and SAP group were significantly higher than those in control group （P〈0. 05）. These levels were （33. 18±5. 40）g / ml, （16. 82±3. 02） mmol / L and （3. 62±0. 56） mmol / L respectively in AMI group, which were significantly higher than those in UAP group and SAP group （P〈0. 05）.The serum levels of Ox-LDL,hs-CRP and cTn Ⅰin patients with severe stenosis were （37. 18±5. 68）g / ml, （17. 80±3. 15） mmol / Land （4. 02±0. 89） mmol / L respectively, which were significantly higher than those of patients with mild and moderate stenosis（P〈 0. 05）. Ox - LDL, hs-CRP and cTnⅠ were positively correlated with Gensini score （ r = 0. 462,0. 414 and 0. 428,P〈0. 05）. Conclusion Serum Ox-LDL, hs-CRP and cTnⅠ are significantly increased in patients with coronary heart disease,which are related to the type of coronary heart disease and the degree of coronary stenosis.

关 键 词：氧化修饰型低密度脂蛋白 超敏C反应蛋白 肌钙蛋白Ⅰ 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]