拉贝洛尔联合甲基多巴对妊娠期高血压疾病患者血流动力学指标及母婴妊娠结局的影响  

Effect of Labetalol Combined with Methyldopa on Maternal Hemodynamic Indexes and Pregnancy Outcomes of Patients with Hypertensive Disorder Complication Pregnancy

作　　者：吕银凤 尉爱红 卢佳[1] 陈德新[1] 张龙[1] 王国华 LYV Yinfeng;YU Aihong;LU Jia;CHEN Dexin;ZHANG Long;WANG Guohua(Department of Obstetrics and Gynecology,Second Hospital of Lanzhou University,Lanzhou 730030,China)

机构地区：[1]兰州大学第二医院妇产科,兰州730030

出　　处：《解放军预防医学杂志》2018年第11期1425-1427,1431,共4页Journal of Preventive Medicine of Chinese People's Liberation Army

摘　　要：目的探讨拉贝洛尔联合甲基多巴治疗妊娠期高血压疾病的疗效,及其对患者血流动力学指标和母婴妊娠结局的影响。方法选取2016年8月-2017年10月本院接诊的妊娠期高血压疾病患者100例作为研究对象,依据随机数字表法平均分为对照组和观察组,对照组患者给予静脉滴注硫酸镁治疗,观察组在对照组治疗基础上给予拉贝洛尔联合甲基多巴治疗。比较两组治疗后有效率、血流动力学指标水平及不良妊娠率。结果观察组治疗后总有效率为92.00%,显著高于对照组的82.00%,差异有统计学意义(χ~2=4.421,P=0.036);观察组治疗后中心静脉压(MAP)、外周阻力水平均显著低于对照组,心脏指数显著高于对照组,差异有统计学意义(P<0.05);观察组不良妊娠率为12.00%,显著低于对照组的28.00%,差异有统计学意义(χ~2=8.000,P=0.005)。结论拉贝洛尔联合甲基多巴可有效提高妊娠期高血压疾病的治疗有效率,改善患者血流动力学指标水平,减少不良妊娠结局的发生。Objective To investigate the therapeutic effect of labetalol combined with methyldopa against hypertensive disorder complication pregnancy, and the effects on hemodynamics and maternal pregnancy outcomes. Methods A total of 100 casesof hypertensive disorder complication pregnancy treated in our hospital between August 2016 and October 2017 were selected asthe subjects. According to the random number table, they were equally divided into the control group and the observation group.The patients in the control group were treated with intravenous infusion of magnesium sulfate, while the observation group was additionally treated with labetalol combined with methyldopa. After treatment, the effective rate, hemodynamic index levels and thebad pregnancy rate were compared. Results The total effective rate in the observation group was 92. 00%, significantly higherthan that of the control group （82. 00%）, so the difference was statistically significant （ x2= 4. 421,P = 0. 036）. The levels ofMAP and peripheral resistance in the observation group were significantly lower than those of the control group, but the heart index was significantly higher than that of the control group, and the difference was statistically significant （P〈0. 05）. The badpregnancy rate of the observation group was 12. 00%, which was significantly lower than that of the control group （28. 00%）,and the difference was statistically significant （x2= 8. 000,P= 0. 005）. Conclusion Labetalol combined with methyldopa can effectively improve the effective rate of hypertensive disorder complication pregnancy, elevate the hemodynamics indexes, and reduce the occurrence of adverse pregnancy outcomes.

关 键 词：妊娠期高血压 拉贝洛尔 甲基多巴 血流动力学 母婴妊娠结局 

分 类 号：R714.252[医药卫生—妇产科学]