猪瘟标记疫苗研究进展  

Research Progress on Classical Swine Fever Marker Vaccines

作　　者：易琳[1] 黎鑫 陈金顶[1] 邹创智 范双旗 马圣明 张媛媛[1] 赵明秋[1] YI Lin;LI Xin;CHEN Jinding;ZOU Chuangzhi;FAN Shuangqi;MA Shengming;ZHANG Yuanyuan;ZHAO Mingqiu(Laboratory of Microbiology and Immunology,College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,China)

机构地区：[1]华南农业大学兽医学院/微生物学与免疫学实验室,广东广州510642

出　　处：《中国猪业》2018年第11期32-37,共6页China Swine Industry

基　　金：国家重点研发计划项目(2017YFD0501104、2017YFD0500600、2016YFD0500700);广州市科技计划项目(201803020005)

摘　　要：猪瘟(classical swine fever,CSF)是一种致病性强、传染性高的烈性疾病,由猪瘟病毒(classical swine fever virus,CSFV)引起并严重危害养猪业。已被世界动物卫生组织(OIE)列为必须报告的动物传染病。过去数十年,防控猪瘟的方法主要是免疫猪瘟弱毒活疫苗,但由于无法区分自然感染与疫苗免疫,研发新型、安全、高效的能将感染和免疫动物区分的标记疫苗是当前及未来猪瘟防控的目标。本文在介绍猪瘟病毒分子特征的同时,总结了已有的猪瘟疫苗以及研发中的新型猪瘟标记疫苗,给猪瘟疫苗的研发和猪瘟的防控提供借鉴。Classical swine fever （CSF） is an acute and highly contagious disease caused by classical swine fever virus （CSFV）, which causes severe damage to the swine industry. And CSF is a notifiable disease and has to be reported to the World Organisation for An mal Health （OIE）. In the past few decades, the main method of preventing and controlling CSF was to immunize live attenuated vac cines. However, due to the inability to differentiate infected from vaccinated animals （DIVA）, the development of new, safe and efficient marker vaccines is the target of current and future prevention and control of CSF. This paper introduced the molecular characteristics of CSFV. At the same time, it summarized the existing vaccine and the new marker vaccine being developed, and provided reference for the development of CSF vaccine and the prevention and control of CSF .

关 键 词：猪瘟 猪瘟病毒 标记疫苗 

分 类 号：S852.52[农业科学—基础兽医学]