心宝丸对老年慢性心功能不全患者运动耐量和B型脑钠肽前体水平的影响  

Effect of Xinbao Pill on exercise tolerance and N-terminal pro-B-type natriuretic peptide level in elderly patients with chronic cardiac insufficiency

作　　者：闵红燕 江柳 张密浓 MIN Hong-yan;JIANG Liu;ZHANG Mi-nong(Department of Pharmacy,Dongguan Qingxi Hospital,Dongguan 523660,China)

机构地区：[1]东莞市清溪医院药剂科,523660

出　　处：《中国实用医药》2018年第32期16-18,共3页China Practical Medicine

基　　金：东莞市社会科技发展项目(项目编号:201650715000922)

摘　　要：目的探讨心宝丸对老年慢性心功能不全患者运动耐量和B型脑钠肽前体水平的影响。方法 80例老年慢性心功能不全患者,随机分为对照组及观察组,各40例。对照组给予常规方法治疗,观察组给予常规方法联合心宝丸治疗。比较两组患者治疗效果,心电图复常时间,治疗前后患者运动耐量和B型脑钠肽前体水平,治疗不良反应。结果观察组患者总有效率为97.50%,高于对照组的75.00%,差异具有统计学意义(P<0.05)。治疗前,两组患者的6 min步行距离、B型脑钠肽前体水平比较,差异均无统计学意义(P>0.05);治疗后,两组患者的6 min步行距离、B型脑钠肽前体水平均较本组治疗前改善,且观察组改善程度优于对照组,差异均具有统计学意义(P<0.05)。观察组心电图复常时间为(3.04±1.01)d,短于对照组的(5.10±2.13)d,差异具有统计学意义(t=5.6512, P<0.05)。观察组治疗不良反应发生率为5.00%,与对照组的7.50%比较,差异无统计学意义(P>0.05)。结论常规方法联合心宝丸治疗老年慢性心功能不全的应用效果确切,可有效改善运动耐量和B型脑钠肽前体水平,加速心电图复常,且无严重不良反应,安全有效,值得推广应用。Objective To discuss the effect of Xinbao Pill on exercise tolerance and N-terminal pro-Btype natriuretic peptide level in elderly patients with chronic cardiac insufficiency. Methods A total of 80 elderly patients with chronic cardiac insufficiency were randomly divided into control group and observation group, with 40 cases in each group. The control group received conventional method for treatment, and the observation group received conventional method combined with Xinbao Pill for treatment. Comparison were made on treatment effect, electrocardiogram recovery time, exercise tolerance and B-type pro-brain natriuretic peptide levels before and after treatment and adverse reactions between the two groups. Results The observation group had higher total effective rate as 97.50% than 75.00% in the control group, and the difference was statistically significant（P〈0.05）. Before treatment, there was no statistically significant difference in 6 min walking distance and N-terminal proB-type natriuretic peptide level（P〈0.05）. After treatment, both groups had better 6 min walking distance and N-terminal pro-B-type natriuretic peptide level than before treatment, and the observation group had better improvement than the control group. Their difference was statistically significant（P〈0.05）. The observation group had shorter electrocardiogram recovery time as（3.04±1.01） d than（5.10±2.13） d in the control group, and the difference was statistically significant（t=5.6512, P〈0.05）. The observation group had no statistically significant difference in incidence of adverse reactions as 5.00%, comparing with 7.50% in the control group（P〈0.05）. Conclusion Combination of conventional method and Xinbao Pill shows affirmative effect in elderly chronic cardiac insufficiency, and it can effectively improve exercise tolerance and N-terminal pro-B-type natriuretic peptide level and quicken electrocardiogram recovery without serious adverse reactions. This method is safe and is worthy of promotion and

关 键 词：心宝丸 老年慢性心功能不全 运动耐量 B型脑钠肽前体水平 

分 类 号：R259[医药卫生—中西医结合]