GLP-1受体激动剂对2型糖尿病患者心肌及血管舒张功能的影响  

Effects of GLP-1 receptor agonists on myocardial function and vasodilatory fuction in patients with type 2 diabetes mellitus

作　　者：于轶楠[1] 梁丽[1] 辛爽清[1] Yu Yi-nan;LIANG Li;XIN Shuang-qing(Department of Endocrinology,Liaoning People＇s Hospital,Shenyang 110016,China)

机构地区：[1]辽宁省人民医院内分泌科,沈阳110016

出　　处：《实用药物与临床》2018年第11期1248-1251,共4页Practical Pharmacy and Clinical Remedies

摘　　要：目的观察胰高血糖素样肽-1(GLP-1)受体激动剂对2型糖尿病患者糖脂代谢、心脏功能及血管舒张功能的影响。方法以2016年1月至2017年1月我院收治的98例2型糖尿病患者为研究对象,依据随机数字表法,将患者随机分为观察组(49例)和对照组(49例),其中观察组采用二甲双胍+GLP-1受体激动剂方案,对照组采用二甲双胍+门冬胰岛素30注射液方案,连续治疗6个月。观察两组患者治疗前后的血糖、血脂、心脏功能及血管舒张功能的变化情况。结果治疗6个月后,两组空腹血糖(FBG)、餐后2 h血糖(2hPG)、糖化血红蛋白(Hb A1c)、三酰甘油(TG)、总胆固醇(TC)明显降低,且观察组低于对照组(P <0. 05);两组左室射血分数(LVEF)及肱动脉血管舒张率均较治疗前显著提高,且观察组高于对照组(P <0. 05)。结论与门冬胰岛素30注射液相比,GLP-1受体激动剂对2型糖尿病患者在降低血糖、调节血脂及心血管保护方面获益更多,值得临床推广。Objective To investigate the effects of glucagon-like peptide-1（ GLP-1） receptor agonists on sugar and lipid metabolism,cardiac functory and vasodilatory function in patients with type 2 diabetes mellitus. Methods A total of 98 patients with type 2 diabetes treated in our hospital from January 2016 to January 2017 were selected. According to random number table method,patients were randomly divided into observation group（ n = 49） and control group（ n = 49）. Observation group was treated with metformin plus GLP-1 receptor agonists,while control group was treated with metformin plus insulin aspartate 30 injection. Both groups were treated for 6 months. The changes of blood glucose,blood lipid,cardiac function and vasodilatory function were observed before and after treatment. Results After 6 months of treatment,the fasting blood glucose（ FBG）,2 h postprandial blood glucose（ 2 hPG）,glycosylated hemoglobin（ Hb A1 c）,triglyceride（ TG） and total cholesterol（ TC） of the patients were decreased,and those in observation group was lower（ P〈0. 05）; the left ventricular ejection fraction（ LVEF） and brachial artery vasodilation rate in both groups were increased compared with those before treatment,and those in observation group was higher（ P〈0. 05）. Conclusion Compared with insulin aspartate 30 injection,GLP-1 receptor agonist has more benefits in lowering blood glucose,regulating blood lipid and cardiovascular protection in type 2 diabetic patients,which is worthy of clinical promotion.

关 键 词：GLP-1受体激动剂 2型糖尿病 血糖 血脂 心肌功能 血管舒张功能 

分 类 号：R587.1[医药卫生—内分泌]