核纤层蛋白B1的功能及其在神经系统疾病和肿瘤中的研究新进展  

Functions of lamin B1 and the new progress of its roles in neurological diseases and tumors

作　　者：刘思阳 伍勇[1] 杨林飞[2] 李小花 黄利华[2] 邢晓为[2] Siyang Liu;Yong Wu;Linfei Yang;Xiaohua Li;Lihua Huang;and Xiaowei Xing(Department of Clinical Laboratory,the Third Xiangya Hospital of Central South University,Changsha 410013,Hunan,China;Center for Experimental Medicine Research,the Third Xiangya Hospital of Central South University,Changsha 410013,Hunan,China（)

机构地区：[1]中南大学湘雅三医院检验科,湖南长沙410013 [2]中南大学湘雅三医院医学实验室,湖南长沙410013

出　　处：《生物工程学报》2018年第11期1742-1749,共8页Chinese Journal of Biotechnology

基　　金：国家自然科学基金(No.30600681);湖南省卫生厅项目(No.B2015-041)资助~~

摘　　要：核纤层蛋白B1 (Lamin B1)是核纤层蛋白家族重要成员之一,其主要功能在于维持细胞核骨架完整性,并通过影响染色体分布、基因表达及DNA损伤修复等参与细胞的增殖和衰老。其表达异常与多种疾病有关,如神经系统疾病(神经管畸形,ADLD)及肿瘤(胰腺癌)等,是潜在的药物靶点和肿瘤标志物。对Lamin B1功能的深入研究,将有助于对相关神经系统疾病和肿瘤发生发展的分子机制的了解并为治疗靶点研究提供新方向。Lamin B1 is one of the essential members of the nuclear lamina protein family. Its main function is to maintain the integrity of nuclear skeleton, as well as to participate in the cell proliferation and aging by affecting the chromosome distribution. gene expression, and DNA damage repair. The abnormal expression of lamin B1 is related to certain diseases, including neurological diseases [e.g. neural tube defects（NDTs）, adult-onset autosomal dominant leukodystrophy（ADLD）] and tumors（e.g. pancreatic cancer）. It is also a potential tumor marker as well as drug target. Further research on lamin B1 will help people understand the molecular mechanism of the emergence and development of neural system diseases and tumors, and define a new future in drug target.

关 键 词：核纤层蛋白B1 细胞核骨架 细胞活动 神经管畸形 肿瘤 

分 类 号：R741[医药卫生—神经病学与精神病学] R730.2[医药卫生—临床医学]