新疆伊犁州未经抗病毒治疗的HIV-1感染者耐药传播水平调查  

Survey of drug resistance transmission in HIV-1 infectors without antiretroviral therapy in Ili prefecture of Xinjiang, China

作　　者：佐合拉.吐尔地 廖玲洁[2] 郑薇薇 王莉[4] 马媛媛[1] 关晓霞[4] 邢辉[2] Zuohela TUERDI;LIAO Ling-jie;ZHENG Wei-wei;WANG Li;MA Yuan-yuan;GUAN Xiao-xia;XING Hui(The Center for Disease Control and Prevention of Xinjiang Uyghur Autonomous Region,Urumqi,Xinjiang 830002,China)

机构地区：[1]新疆维吾尔自治区疾病预防控制中心,乌鲁木齐830002 [2]中国疾病预防控制中心,北京102206 [3]新疆伊宁市人民医院,新疆伊宁835000 [4]新疆伊犁哈萨克自治州疾病预防控制中心,新疆伊宁835000

出　　处：《疾病预防控制通报》2018年第5期13-15,共3页Bulletin of Disease Control & Prevention(China)

基　　金：国家"十二五"科技重大专项(2012ZX1001-002)

摘　　要：目的了解新疆伊犁哈萨克自治州(简称伊犁州)未经抗逆转录病毒治疗的HIV-1感染者耐药毒株传播水平。方法以2013年1—6月和2014年1—6月新诊断的HIV-1感染者为研究对象,抽血分离血浆后检测基因型耐药性,应用Stanford HIV Drug Resistance Database(http://hivdb.stanford.edu)的在线耐药序列分析软件分析病毒亚型和耐药突变情况。结果共收集401例感染者的样本及信息,检测到335份样本的基因序列,扩增率83.5%,335份样本中耐药22例、耐药率6.6%;病毒亚型以CRF07-BC为主(95.8%),其次还有B亚型(0.9%)及CRF01-AE(3.3%)。结论伊犁州未经抗病毒治疗的HIV感染者中有HIV耐药毒株传播;为保证抗病毒治疗的效果,需加强感染者在抗病毒治疗开始前与后耐药基因突变检测,针对HIV耐药传播和发生的原因积极采取措施。Objective To know the transmission level of drug-resistant HIV-1 strains among HIV-1 infected patients without antiretroviral therapy in Ili Kazak Autonomous Prefecture（Ili prefecture） of Xinjiang. Methods The new patients with HIV-1 infection were confirmed from January to June in 2013 and 2014 and selected as the subjects. The plasma was separated from the blood of the subjects of detection for genotypic resistance. The viral subtype and mutation of drug resistance were analyzed with the online software of drug resistance sequence analysis released by Stanford HIV Drug Resistance Database（http：//hivdb.stanford.edu）. Results Totally, information and blood samples of the 401 patients were collected within two years. Gene sequence of 335 samples was successfully detected, with amplification rate of 83.5%. Out of the 335 samples, there were 22 samples of drug resistance, with the drug resistance rate of 6.6%. The subtype of HIV was mainly CRF07-BC（95.8%）, then subtype B（0.9%） and CRF01-AE（3.3%）. Conclusions The strains with transmitted drug resistance exist in the HIV-1 infectors without antiviral therapy in Ili prefecture. In order to ensure the effect of antiretroviral therapy, the detection for drug-resistant gene mutation should be strengthened before and after the antiretroviral therapy, and the positive measures should be taken aiming at the transmission and occurrence of HIV resistance.

关 键 词：HIV 抗病毒治疗 耐药传播 

分 类 号：R512.91[医药卫生—内科学]