河南省部分地区2006-2015年艾滋病患者流行病学及临床特征分析  

Analysis of AIDS epidemic and clinical features in some part regions of Henan province during 2006-2015

作　　者：孙燕[1] 陈昭云[1] 杨萱[1] 张雪[1] 李超锋[1] 赵清霞[1] Sun Yan;Chen Zhaoyun;Yang Xuan;Zhang Xue;Li Chaofeng;Zhao Qingxia(Department of Second Infectious Diseases,the Sixth People＇s Hospital of Zhengzhou,Zhengzhou,He＇nan 450015,China)

机构地区：[1]郑州市第六人民医院感染二科,河南省郑州450015

出　　处：《中国基层医药》2018年第21期2761-2764,J0001,共5页Chinese Journal of Primary Medicine and Pharmacy

基　　金：“十二五”艾滋病和病毒性肝炎等重大传染病防治科技重大专项（2012ZX10001-003-001）;河南省科技攻关计划项目（162102310217）

摘　　要：目的探讨河南省部分地区艾滋病（AIDS）患者流行病学及临床特点。方法选择2006-2015年郑州市第六人民医院收治的AIDS患者10 324例次为研究对象进行流行病学以及临床特征分析。结果2006-2015年住院人次数逐年上升，10年平均增长率为20.31%；患者年龄（43.91±13.56）岁，40～60岁年龄组占54.06%，职业以农民为主占71.12%；2006-2015年间患者传播途径发生了很大变化，2008年以前以血液传播为主占72.72%，2013年以后以性传播为主占59.69%。患者合并2种以上机会感染者占40.41%，机会性感染发病率较高的前五位分别是：细菌性肺炎（32.68%）、肺结核（19.29%）、真菌感染（18.65%）、肺孢子菌肺炎（12.96%）、肺外结核（7.45%）。患者病死率5.79%，外周血CD4细胞数与疾病严重程度及预后密切相关。结论早期开展抗病毒治疗，控制机会性感染是缓解病情，降低病死率的重要环节。Objective To discuss the epidemiology and clinical characteristics of AIDS in some part of Henan regions.Methods Retrospective analysis was conducted based on the clinical and epidemic information collected from AIDS patients who were treated in the Sixth People＇s Hospital of Zhengzhou between 2006 and 2015 in He＇nan province.Results Between 2006 and 2015, the number of hospitalization increased every year.The average growth rate was 20.31%.The average age of patients was （43.91±13.56） years old.The patients from 40 to 60 years old group occupied 54.06% of total patients, and 71.12% of patients were farmers.During 2006 to 2015, the propagation path changed a lot.Before 2008, blood transmission was the major propagation path （72.72%）, but after 2013, the major propagation path was sexual activity （59.69%）.40.41% of patients were infected by two or more opportunistic infections.The top five opportunistic infections were bacterial pneumonia （32.68%）, tuberculosis （19.29%）, fungal infection （18.65%）, pneumocystis carinii pneumonia （12.96%）, extra pulmonary tuberculosis （7.45%）. The death rate was 5.79%.The number of CD4 cells in peripheral blood was closely related to the severity of illness.Conclusion Early anti-virus treatment and opportunistic infection control are key factors to relieve the severity of illness and reduce the death rate.

关 键 词：获得性免疫缺陷综合征 艾滋病相关机会致病菌感染 流行病学 

分 类 号：R512.91[医药卫生—内科学]