抗凝药相关肾病与年龄相关肾功能减退及慢性肾病的关系  

Anticoagulant-related nephropathy and age-associated renal impairment and chronic kidney disease

作　　者：于慧春[1] 马晓炳 郝媛媛[1] 王萍[1] 史娜[2] 王育强 李贺[2] YU Hui-chun;MA Xiao-bing;HAO Yuan-yuan;WANG Ping;SHI Na;WANG Yu-qiang;LI He(Department of Geriatrics,Xiqing Hospital,Tianjin 300380,China)

机构地区：[1]天津市西青医院老年病科,天津300380 [2]武警后勤学院附属医院老年病科,天津300162

出　　处：《武警后勤学院学报（医学版）》2018年第5期453-456,共4页Journal of Logistics University of PAP（Medical Sciences）

基　　金：天津市西青医院科研基金项目(xqyylx201704)

摘　　要：抗凝药相关肾病(anticoagulant-related nephropathy,ARN)是指过度抗凝治疗(国际标准化比值>3.0)引起的急性肾损伤。ARN与年龄相关的肾功能减退及慢性肾病关系密切,长期预后不良。随着人口老龄化,因相关疾病需抗凝治疗的老年人逐年增多,ARN病例报告随之增加,受到关注,然而ARN确切发生机理和防治对策均不清楚。Anticoagulant- related nephropatby （ARN） is currently defined as acute kidney injury induced by over-anticoagulation in the setting of an International Normalized Ratio of 〉 3.0. ARN is linked closely to age- associated renal impairment and chronic kidney disease and related to poor outcomes in these patients. As population ageing, the thromboemholic disease is a common medical condition in the elderly population, which result in substantially increasing requirement of anticoagulation therapy, therefore, inevitably lead to an increasing number of cases of ARN. But the possible mechanisms underlying of the adverse effect is still obscure and no effective prevention and treatment strategy are available at present. Thus ARN is paid a more attention broadly.

关 键 词：口服抗凝药 抗凝药相关肾病 慢性肾病 肾功能减退 老年人 

分 类 号：R692[医药卫生—泌尿科学]