恩替卡韦抗病毒治疗对肝癌HBV感染患者术后预后的影响  

Effect of Entecavir Antiviral Therapy on Postoperative Prognosis of Patients with Hepatocellular Carcinoma HBV Infection

作　　者：曹健[1] CAO Jian(First People＇s Hospital of Jiujiang City,Jiujiang Jiangxi 332000,China)

机构地区：[1]江西省九江市第一人民医院,江西九江32000

出　　处：《药品评价》2018年第23期52-55,共4页Drug Evaluation

基　　金：江西省卫生计生委科技计划(课题编号:20175294)

摘　　要：目的:探究恩替卡韦抗病毒治疗对肝癌HBV感染患者术后预后的影响。方法:选取在江西省九江市第一人民医院接受手术治疗的40例肝癌HBV感染患者作为研究对象,选用随机数字表法将其分为参照组和研讨组,每组20例。参照组不给予抗病毒治疗,研讨组给予恩替卡韦进行抗病毒治疗,对两组患者的临床效果进行观察比较。结果:观察两组患者术前术后的HBV-DNA水平发现,术前两组无显著差异(P>0.05),术后研讨组HBV-DNA水平低于参照组,P<0.05,两组间差异显著且存在统计学意义。观察两组患者的术前术后肝功能指标发现,术前两组患者的肝功能指标无显著差异(P>0.05),术后研讨组的肝功能指标均显著优于参照组,P<0.05,两组间差异显著且存在统计学意义。观察两组患者术后并发症情况发现,研讨组总发生率显著高于参照组,P<0.05,两组间差异显著且存在统计学意义。观察两组患者术后复发率情况发现,研讨组总复发率低于对照组,P<0.05,两组间差异显著且存在统计学意义。结论:恩替卡韦抗病毒治疗对肝癌HBV感染患者术后预后的影响良好,值得在临床上推广应用。Objective To investigate the effect of entecavir antiviral therapy on postoperative prognosis of patients with hepatocellular carcinoma （HBV） infection. Methods： A total of 40 patients with HBV infection of liver cancer received surgical treatment in our hospital were selected and randomly divided into two groups： the control group （n=20） and the study group （n=20）. The control group was not treated with antiviral therapy, and the study group was treated with entecavir. The clinical effects of the two groups were observed and compared. Results： The HBV-DNA levels of the two groups were observed before and after operation. There was no signi-cant difference between the two groups before and after operation （P〉0.05）. The HBV-DNA level in the study group after operation was signi-cant compared with the control group （P〈0.05）. The results showed that there was no signi-cant difference in liver function between the two groups （P〉0.05）. The indexes of liver function in the study group were signi-cantly better than those in the control group （P〈0.05）. The incidence of postoperative complications in the study group was signi-cantly higher than that in the control group （P〈0.05）. The overall recurrence rate of the study group was signi-catly lower than that of the control group （P〈0.05）. Conclusion： The antiviral therapy of entecavir has a good effect on postoperative prognosis of patients with HBV infection of liver cancer, and it is worth popularizing in clinic.

关 键 词：恩替卡韦 抗病毒治疗 肝癌HBV感染 术后预后 影响 

分 类 号：R978.7[医药卫生—药品]