超敏C-反应蛋白、白细胞计数、红细胞沉降率、床旁降钙素原在小儿呼吸道感染中的联合检测价值  

Value of combined detection of hypersensitive C-reaction,white blood cell count,erythrocyte sedimentation rate and bedside procalcitonin in children′s respiratory tract infection

作　　者：曾纪扬 陈美桂 莫志宇 ZENG Jiyang;CHEN Meigui;MO Zhiyu(Department of Clinical Laboratory,Maternity and Child Health Care Hospital ofYingde,Yingde,Guangdong 513000,China)

机构地区：[1]广东省英德市妇幼保健计划生育服务中心检验科,513000

出　　处：《检验医学与临床》2018年第23期3495-3498,共4页Laboratory Medicine and Clinic

基　　金：广东省清远市科技创新计划项目(2014B124)

摘　　要：目的探讨超敏C-反应蛋白(hs-CRP)、白细胞计数(WBC)、红细胞沉降率(ESR)和床旁降钙素原(PCT)在小儿呼吸道感染中的联合检测价值。方法选取呼吸道感染婴幼儿患者180例,分为细菌组102例和非细菌组78例,另选取同期健康体检幼儿90例作为对照组,所有研究对象检测hs-CRP、WBC、ESR和床旁PCT。结果细菌组的各项指标均显著高于对照组和非细菌组,差异有统计学意义(P<0.05);非细菌组床旁PCT显著高于对照组,差异有统计学意义(P<0.05)。细菌组和非细菌组的各项指标单独检测和联合检测阳性率均明显高于对照组,差异有统计学意义(P<0.05);细菌组患者床旁PCT、hs-CRP水平显著高于非细菌组,差异有统计学意义(P<0.05)。各项指标联合检测的灵敏度、特异度和准确度高于单独检测,差异有统计学意义(P<0.05);其中,PCT的灵敏度、特异度和准确度均高于其他指标,差异有统计学意义(P<0.05)。结论 hs-CRP、WBC、ESR和床旁PCT联合检测灵敏度、特异度、准确度较高,可以鉴别细菌与非细菌性小儿呼吸道感染,为临床合理用药提供依据。Objective To discuss the combined detection of hypersensitive C-reaction （hs-CRP）,white blood cell count （WBC）,erythrocyte sedimentation rate （ESR） and bedside procalcitonin （PCT） in children′s respiratory tract infection. Methods A total of 180 infants with respiratory infection were selected and divided into bacterial group （102 cases） and non-bacterial group （78 cases）,while 180 healthy children in the same period were selected as the control group.Hs-CRP,WBC,ESR and bedside PCT were detected in all the subjects. Results The indicators of bacteria group were significantly higher than those of control group and non-bacterial group,and the differences were statistically significant （ P 〈0.05）.The bedside PCT of non-bacteria group was significantly higher than that of control group,and the difference was statistically significant （ P 〈0.05）.As far as the positive rates of separate and combined detection,bacterial infection group and non-bacterial group were significantly higher than control group,the differences were statistically significant （ P 〈 0.05 ）.Beside PCT,hs-CRP level of bacterial group was significantly higher than that of non-bacterial group,and the differences were statistically significant （ P 〈0.05）.Compared with the single test,the sensitivity,specificity and accuracy of combined detection of each index increased significantly and the difference was statistically significant （ P 〈0.05）.The sensitivity,specificity and accuracy of PCT were all higher than those of other indicators,and the differences were statistically significant （ P 〈0.05）. Conclusion The combined detection of hs-CRP,WBC,ESR and bedside PCT have higher sensitivity,specificity and accuracy in differential diagnosis in bacterial and non-bacterial respiratory infections in children,which could provide evidence for clinical rational drug use,so as to achieve early diagnosis,accurate medication and better prognosis.

关 键 词：呼吸道感染 降钙素原 超敏C-反应蛋白 白细胞计数 红细胞沉降率 

分 类 号：R446.1[医药卫生—诊断学]