复方抗骨质增生缓释片治疗膝关节骨性关节炎的对照研究  

Case-control Study on Treating Knee Osteoarthritis by Compound Anti-hyperosteogeny Sustained-release Tablets

作　　者：施星臣[1] 孙仕华[1] 吕黎 李晓强[3] 王经韬[1] 许筠[1] 余利军[4] SHI Xingchen;SUN Shihua;LYU Li;LI Xiaoqiang;WANG Jingtao;XU Jun;YU Lijun(The Second People＇s Hospital of Lanzhou City,Lanzhou 730046,China;Gansu University of Chinese Medicine;Lanzhou University Second Hospital;Gansu Provincial Hospital)

机构地区：[1]兰州市第二人民医院,甘肃兰州730046 [2]甘肃中医药大学 [3]兰州大学第二医院 [4]甘肃省人民医院

出　　处：《西部中医药》2018年第11期7-10,共4页Western Journal of Traditional Chinese Medicine

基　　金：甘肃省青年科技基金计划(编号1506RJYA315)

摘　　要：目的:观察复方抗骨质增生缓释片治疗膝关节骨性关节炎的临床疗效。方法:将膝关节骨性关节炎患者140例按随机数字表法分为试验组和对照组各70例。对照组给予超短波理疗机治疗,试验组口服复方抗骨质增生缓释片治疗。4周为1个疗程,2组均治疗4个疗程后观察并记录患者Lesquesne评分以及基质金属蛋白酶9(MMP-9)、肿瘤坏死因子α(TNF-α)、白细胞介素1(IL-1)、白细胞介素6(IL-6)炎性介质的水平。结果:1个疗程后,2组患者的休息痛、运动痛、压痛、肿胀、晨僵及行走能力均得到不同程度改善,Lesquesne指数呈下降趋势;4个疗程后治疗组有效率为75.7%(53/70),高于对照组的65.7%(46/70),差异有统计学意义(P<0.05)。Lesquesne指数2组比较差异有统计学意义(P<0.05),但休息痛、肿胀、晨僵2组比较差异无统计学意义(P>0.05)。2组患者TNF-α,MMP-9、IL-1、IL-6水平1个疗程后呈下降趋势,4个疗程后2组比较差异有统计学意义(P<0.05)。结论:复方抗骨质增生缓释片治疗膝关节骨性关节炎疗效优于超短波理疗,其作用机制可能与抗炎性因子的表达有关。Objective： To explore clinical effects of compound anti-hyperosteogeny sustained-release tablets intreating knee osteoarthritis （KOA）. Methods： All 140 KOA patients were randomized into the experiment group andthe control group according to random number table method, 70 cases each group. The patients in the control groupwere treated by ultra-short wave physical therapy, and the ones in the experiment group took compoundanti-hyperosteogeny sustained-release tablets orally. Four weeks were one course, the levels of inflammatory factorssuch as IL-6, IL-1, TNF-α, MMP-9 and Lesquesne scores of the patients were observed and recorded after they weretreating for four courses. Results： After one course, rest pain, motion pain, tenderness, swelling, morning stiffness andwalking ability of the patients in both groups were group improved to different degrees, Lesquesne index showed thedecreasing tendency; by the end of the forth course, the effective rate of the treatment group was 75.7% （53/70）, ithad statistical meaning when compared with 65.7%（46/70） the control group（P〈0.05）. The difference had statistical meaning in the comparisons of Lesquesne indexes between both groups（P〈0.05）, while the difference had nostatistical meaning in the comparisons of rest pain,swelling and morning stiffiness between both groups（P〉0.05）.After one course, the level of TNF-α, MMP-9, IL-1 and IL-6 presented the tendency of lowering in the patients of theexperiment group; by the end of the forth course, the difference was statistically significant when motion pain,tenderness and walking ability of the experiment group were compared with these of the control group（P〈0.05）.Conclusion： The mechanism of compound anti-hyperosteogeny sustained-release tablets in treating KOA might befighting against the expressions of inflammatory factors.

关 键 词：骨质增生 骨性关节炎 膝 炎性因子 复方抗骨质增生缓释片 

分 类 号：R684.3[医药卫生—骨科学]