耳后骨膜下注射甲泼尼龙治疗合并2型糖尿病的突发性聋的疗效分析  

Treatment of sudden deafness with type 2diabetesmellitus by post-auricular subperiosteal injection of methylprednisolone

作　　者：王鑫[1,2] 刘昕笛[3] 赵博 杨诗雨[4] 曹亚茹 张文 刘晖[2] WANG Xin;LIU Xindi;ZHAO Bo;YANG Shiyu;CAO Yaru;ZHANG Wen;LIU Hui(Xi＇an Jiaotong University,Xi＇an 710049,China;Zhejiang University School of Medicine;Xi＇an Medical University;Department of Otolaryngology Head and Neck Surgery,Shaanxi Provincial People＇s Hospital)

机构地区：[1]西安交通大学,西安710049 [2]陕西省人民医院耳鼻咽喉头颈外科,西安710068 [3]浙江大学医学院 [4]西安医学院

出　　处：《临床耳鼻咽喉头颈外科杂志》2018年第22期1719-1722,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:探讨耳后骨膜下注射甲泼尼龙联合银杏叶提取物注射液及鼠神经生长因子在合并2型糖尿病的突发性聋中的治疗效果及对血糖水平的影响,探讨治疗该类型突发性聋有效且安全的方法。方法:选择伴发2型糖尿病的突发性聋患者84例,随机分为试验组(耳后骨膜下注射甲泼尼龙+银杏叶提取物注射液、鼠神经生长因子)48例及对照组(单纯给予银杏叶提取物注射液、鼠神经生长因子)36例,每组按不同听力曲线类型分为低频下降、高频下降及平坦与全聋3个小组。比较试验组与对照组患者的临床疗效及试验组治疗前后血糖波动和糖化血红蛋白的差异。结果:(1)试验组治疗的有效率为79.17%,高于对照组的有效率58.33%,差异有统计学意义(P<0.05)。说明耳后骨膜下注射甲泼尼龙联合银杏叶提取物注射液、鼠神经生长因子在合并2型糖尿病的突发性聋中疗效确切。(2)试验组治疗前后血糖浓度波动及糖化血红蛋白水平差异无统计学意义,说明该治疗方式可以有效避免激素的全身不良反应,保证治疗的安全性。结论:耳后骨膜下注射甲泼尼龙联合银杏叶提取物注射液及鼠神经生长因子治疗合并2型糖尿病的突发性聋患者有显著疗效,且激素使用不会对血糖产生影响,避免激素全身不良反应的发生。Objective：To investigate the therapeutic effect of post-auricular subperiosteal injection of methylprednisolone combined with ginkgo biloba injection and mouse nerve growth factor in sudden deafness with type 2 diabetesmellitus.To understand the effect of post-auricular subperiosteal injection of methylprednisolone on type 2 diabetesmellitus complicated with sudden deafness and its effect on blood-glucose level,and to explore a more effective and safe method for treating this special group of sudden deafness.Method：Total 84 patients suffered from type 2 diabetesmellitus with sudden deafness and treated in Shaanxi Provincial People＇s Hospital from March 2017 to June 2018 were randomly divided into experimental group（post-auricular subperiosteal injection of methylprednisolone＋ginkgo biloba injection,mouse nerve growth factor）（n=48）and a control group（ginkgo biloba injection,mouse nerve growth factor）（n=36）.Each group was divided into high frequency,low frequency and flat and total deafness group.Then to compare the clinical efficacy of the two groups and the difference of the fluctuation of blood glucose and HbA1 cbefore treatment and 2 hours after treatment.Result：（1）The effective rate of treatment in the experimental group was 79.17%,higher than that in the control group（58.33%）,P〈0.05.The results indicated that the effect of post-auricular subperiosteal injection of methylprednisolone combined with ginkgo biloba injection and mouse nerve growth factor was effective in sudden deafness with type 2 diabetesmellitus.（2）There was no significant difference in the fluctuation of blood glucose and HbA1 cbefore treatment and 2 hours after treatment in the experimental group,and it indicated that this treatment can effectively avoid systemic side effects of steroid and ensure the safety of the treatment.Conlusion：Post-auricular subperiosteal injection of methylprednisolone combined with ginkgo biloba injection and mouse nerve growth factor is effective in patients with sudden dea

关 键 词：突发性聋 2型糖尿病 甲泼尼龙 

分 类 号：R764.43[医药卫生—耳鼻咽喉科]