健身气功治疗慢性阻塞性肺疾病稳定期随机对照试验系统评价  

Gymnastic Qigong in the Treatment of Chronic Obstructive Pulmonary Disease Stabilization:A Systematic Review of Randomized Controlled Trials

作　　者：李际强 刘娜 云芯芯 张忠德 汶希 张溪 蔡倩 LI Jiqiang;LIU Na;YUN Xinxin;ZHANG Zhongde;WEN Xi;ZHANG Xi;CAI Qian(The Second Affiliated HosDital of Guangzhou University of Chinese Medicine,Guangzhou 510006,Gaungdong,China;Guangzhou University of Chinese Medicine,Guangzhou 510006,Gaungdong,China)

机构地区：[1]广州中医药大学第二附属医院大学城医院

出　　处：《辽宁中医药大学学报》2018年第11期5-9,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家中医药管理局科研基金项目(JDZΧ2012034);国家体育总局健身气功管理中心重点项目(QG11A02;QG2016042)

摘　　要：目的：系统评价健身气功对慢性阻塞性肺疾病（COPD）稳定期的临床疗效。方法：计算机检索PubMed、Central（Cochrane library）、Embase、CNKI、VIP、WanFang Data、CBM等数据库,检索有关中医气功治疗COPD稳定期的随机对照研究（RCT）,检索时限均为自建库至2018年1月,由两位研究者独立按照纳入与排除标准文献筛选、资料提取和质量评价后,采用RevMan 5.3软件进行Meta分析。纳入20个随机对照研究,共1824例患者。结果：与基础治疗比较,中医健身气功疗法联合基础治疗能有效改善患者肺功能,FEV1%[MD=5.34,95%CI（2.70,7.98）,P〈0.0001]、[MD=5.35,95%CI（2.58,8.12）,P=0.0001];FEV1/FVC（%）：[MD=4.49,95%CI（1.66,7.31）,P=0.002]、[MD=2.53,95%CI（0.38,4.68）,P=0.02]）。改善患者生活质量,CAT评分[MD=-4.18,95%CI（-5.52,-2.84）,P〈0.00001],提高患者运动耐力,6MWD[MD=22.10,95%CI（12.43,31.78）,P〈0.00001]、[MD=44.46,95%CI（20.59,68.34）,P=0.0003]）。结论：研究结果显示,与基础治疗相比,中医传统健身气功联合基础治疗可提高COPD稳定期患者运动耐力、改善肺功能和生活质量。由于纳入的部分研究的质量不佳,以上结论还有待于更多研究予加以验证。Objective：To evaluate the efficacy of gymnastic Qigong in treating chronic obstructive pulmonary disease（COPD）in stable stage. Methods：We electronically searched databases including PubMed,Central（Cochrane library）,Embase,CNKI,VIP,CBM and WanFang Data to collect randomized controlled trials（RCTs）regarding Qigong in treating stable COPD from inception to January 2018. Two reviewers independently screened literature,extracted data and assessed the risk of bias of the included studies. Meta-analysis was conducted by RevMan 5.3 software. Results：A total of 20 RCTs involving 1824 patients were included. The results of Meta-analysis showed that：when compared with conventional symptomatic treatment alone,gymnastic Qigong combined with the symptomatic significantly improved lung function,FEV1%[MD=5.34,95%CI（2.70,7.98）,P〈0.0001,MD=5.35,95%CI（2.58,8.12）,P=0.0001];FEV1/FVC（%）[MD=4.49,95%CI（1.66,7.31）,P=0.002],[MD=2.53,95%CI（0.38,4.68）,P=0.02],decreased CAT score（[MD=-4.18,95%CI（-5.52,-2.84）,P〈0.00001]. Increased exercise endurance,6 MWD[MD=22.10,95%CI（12.43,31.78）,P〈0.00001,MD=44.46,95%CI（20.59,68.34）,P=0.0003]. Conclusion：The current evidence shows that combination of gymnastic Qigong and symptomatic treatment may increase exercise endurance in patients with stable COPD and improve quality of life. Due to the limited quality and quantity of included studies,the above results are needed to verify by more studies.

关 键 词：健身气功 慢性阻塞性肺疾病 系统评价 Meta分析 随机对照试验 

分 类 号：R563.5[医药卫生—呼吸系统]