清肾颗粒对慢性肾衰竭伴颈动脉斑块患者血清Tm、PGI2水平影响  

Effect of Qingshen Granule on Serum TM and PGI2 Levels in Patients with Chronic Renal Failure with Carotid Plaque

作　　者：余屹 吕勇[2] 金华[2] 王东[2] 王亿平[2] YU Yi;LYU Yong;JIN Hua;WANG Dong;WANG Yiping(Anhui University of Chinese Medicine,Hefei 230038,Anhui,China;The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230031,Anhui,China)

机构地区：[1]安徽中医药大学,安徽合肥230038 [2]安徽中医药大学第一附属医院,安徽合肥230031

出　　处：《辽宁中医药大学学报》2018年第11期83-86,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81673931)

摘　　要：目的：探讨清肾颗粒对慢性肾衰竭伴颈动脉斑块湿热证患者血栓调节蛋白（Tm）、前列环素（PGI2）水平的干预作用。方法：选择CKD 3～5期非透析伴颈动脉斑块湿热证患者70例,根据随机数据表分成实验组和对照组,每组35例,实际完成62例,实验组33例,对照组29例,并选取健康人20例作为正常组。实验组和对照组均予常规治疗,实验组加用清肾颗粒,1次1袋,1 d 3次,疗程均为6个月。观察治疗前后血肌酐（Scr）、尿素氮（BUN）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）的水平及颈动脉中内膜厚度（IMT）,并应用ELISA法测定血清Tm、PGI2水平。结果：（1）对照组治疗前后IMT厚度无明显变化（P〉0.05）,实验组治疗后较治疗前IMT厚度明显缩小（P〈0.01）,且较对照组下降明显（P〈0.01）;（2）与本组治疗前比较,治疗后实验组SCr、BUN、TG、TC、LDL-C水平明显下降（P〈0.05）,HDL-C水平明显升高（P〈0.05）,对照组治疗前后以上指标无明显变化（P〉0.05）;（3）与正常组比较,治疗前实验组和对照组血清Tm水平升高（P〈0.01）、血清PGI2水平下降（P〈0.01）;与本组治疗前比较,治疗后实验组血清Tm水平下降（P〈0.01）、血清PGI2水平升高（P〈0.01）;而对照组治疗前后血清Tm、PGI2水平均无明显差异（P〉0.05）;（4）血清Tm水平与IMT呈正相关（r=0.268,P=0.035）,血清PGI2水平与IMT呈负相关（r=-0.397,P=0.001）。结论：清肾颗粒可以改善慢性肾衰竭患者颈动脉斑块程度,其机制可能与降低患者血清Tm,升高血清PGI2及调节血脂水平有关。Objective：To investigate the effect of Qingshen Granule（QG）on the level of thrombomodulin（Tm）and prostacyclin I2（PGI2）in chronic renal failure（CRF）patients with dampheat syndrome（DHS）of carotid artery plaque. Methods：To select 70 cases of CKD3-5 non-dialysis patients with damp-heat syndrome（DHS）of carotid artery plaque,they were divided into experimental group and control group by randomly numerical table,35 in each group. Actually 62 patients completed,33 in the experimental group and 29 in the control group. And in the meantime,20 persons who had taken physical health were assigned in the normal group. All patients received routine treatment. Patients in the experimental group additionally took QG,1 package each time,3 times per day. The therapeutic course for all was six months. The level of serum creatinine（SCr）,urea nitrogen（BUN）,triglyceride（TG）,totalcholesterol（TC）,high-density lipoprotein（HDL-C）,low-density lipoprotein（LDL-C）and the intima-media thickness（IMT）were observed before and after treatment,the levels of Tm and PGI2 were measured by enzyme-linked immunosorbent assay（ELISA）in plasma. Results：（1）There was no significant change in IMT thickness before and after treatment in the control group（P〉0.05）;The IMT thickness of the experimental group was significantly reduced before and after treatment（P〈0.01）,and decreased significantly than the control group（P〈0.01）.（2）Compared with before treatment in the same group,the level of SCR,BUN,TG,TC and LDL-C all decreased in the experimental group after treatment（P〈0.05）,and HDL-C level increased obviously（P〈0.05）;The control group had no significant changes in the above indexes before and after treatment（P〉0.05）.（3）Compared with the normal group,serum Tm levels were significantly higher and serum PGI2 levels were obviously lower in the experimental group and the control group before treatment（P〈0.01）;Compared with before treatment,the levels of

关 键 词：清肾颗粒 血清血栓调节蛋白 血清前列环素 颈动脉斑块 

分 类 号：R692.5[医药卫生—泌尿科学]