药用植物萜类成分异源生产和表达研究进展  

Advances in Studies on the Heterologous Production and Expression of Terpenoids in Medicinal Plants

作　　者：赵振华[1] 李媛[1,2] 马云 戚莹雪 李哲 玄静 张永清[1] ZHAO Zhenhua;LI Yuan;MA Yun;QI Yingxue;LI Zhe;XUAN Jing;ZHANG Yongqing(Shandong University of Traditional Chinese Medicine,Jinan 250355,Shandong,China;National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]山东中医药大学,山东济南250355 [2]中国中医科学院中药资源中心,北京100700

出　　处：《辽宁中医药大学学报》2018年第10期99-102,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家公益性行业(农业)科研专项项目(201407002);国家科技重大专项项目(2010ZX09401-302-5-12);山东省中医药科技发展计划项目(2015-045)

摘　　要：药用植物萜类成分具有广泛的生物活性,已被用于临床并有较好疗效。萜类化合物主要来自于自然资源,产量较低,由于药材市场需求量逐年递增、自然资源逐渐减少,供不应求的局面较为严重。随着对其代谢工程和合成生物学研究的逐步深入,萜类化合物种类和产量大幅度增加。该文围绕萜类化合物药用植物萜类成分在异源表达宿主中生产及表达的成功应用进行综述,这对于推进萜类化合物的工业化合成生产、增加萜类化合物多样性和中药资源的可持续利用具有十分重要的现实意义和应用价值。Terpenoids in medicinal plants have a wide range of biological activities,they have been used in clinic and have good curative effects. Terpenoids mainly come from natural resources but the yield is low. Because the market demand of medicinal materials increases year by year,natural resources decrease gradually,the situation of supply exceeds demand is serious. With the development of metabolic engineering and synthetic biology,the species and yield of terpenoid have been greatly increased. This paper focuses on the successful production and expression of terpenoids in heterologous expression host. It is of great practical significance in promoting industrialization,synthesis and production of terpenoids,increasing diversity of terpenoids and sustainable utilization of traditional Chinese medicine resources.

关 键 词：药用植物 萜类化合物 异源合成 生产及表达 天然产物 

分 类 号：R282.71[医药卫生—中药学]