甘肃省宕昌县利什曼原虫感染人群的家庭聚集性与空间聚集性分析  

Investigation on the Familial Aggregation and Spatial Aggregation of People Infected With Leishmania in Tanchang County of Gansu Province

作　　者：白雪飞 官亚宜[2] 伍卫平[2] 王立英[2] 韩帅[2] 王莹[2] 朱曜宇[2] 冯宇 李凡[3] 任德毅[3] 杨国兵[3] BAI Xuefei;GUAN Yayi;WU Weiping;WANG Liying;HAN Shuai;WANG Ying;ZHU Yaoyu;FENG Yu;LI Fan;REN Deyi;YANG Guobing(Sichuan Center for Disease Control and Prevention,Chengdu 610041,Sichuan Province,China;Key Laboratory of Parasite and Vector Biology,Ministry of Health,WHO Collaborative Center for Tropical Diseases,National Institute of Parasitic Diseases,Chinese Center for Disease Control and Prevention,Shanghai 200025,China;Gansu Center for Disease Control and Prevention,Lanzhou 730000,Gansu Province,China.)

机构地区：[1]四川省疾病预防控制中心,成都610041 [2]中国疾病预防控制中心寄生虫病预防控制所、世界卫生组织热带病合作中心、卫生部寄生虫病原与媒介生物学重点实验室,上海200025 [3]甘肃省疾病预防控制中心,兰州730000

出　　处：《预防医学情报杂志》2018年第12期1502-1506,1512,共6页Journal of Preventive Medicine Information

摘　　要：目的 为了解甘肃省宕昌县沙湾乡山丘型黑热病流行区人群利什曼原虫感染的分布是否存在家庭、空间聚集性特征,为山丘型黑热病防控工作及后续研究提供参考。方法 本研究结合甘肃宕昌县现场调查的人群血样巢式PCR检测结果与手持GPS对受访家庭的定位数据,进行了二项分布拟合优度χ^2检验和Scan统计分析。结果 调查两个行政村的96户家庭,215人。215名受检者中,巢式PCR检测结果为阳性者有49人,人群阳性率为22. 8%（49/215）; 96户家庭中,有巢式PCR检测阳性受检者的有41户,占42. 7%（41/96）。χ^2检验显示本次受访家庭中利什曼原虫感染者的分布服从二项分布（P〉0. 05）; Scan分析提示不同地域间人群利什曼原虫的感染水平差异无统计学意义（P〉0. 05）。结论 本次调查虽未发现甘肃省宕昌县黑热病流行区利什曼原虫人群感染呈现家庭聚集性或空间聚集性分布特征,但巢式PCR检测阳性率高,提示当地仍需广泛全面开展黑热病预防控制,重点落实驱蛉灭蛉工作。Objective To investigate whether the distribution of people infected with Leishmania in the hill - type kala- azar popular area in Shawan town, Tanchang county, Gansu province showed the characteristics of familial aggregation and spatial aggregation, so as to provide a reference for the further research and control of kala-azar disease. Methods Nest PCR detection of human sera and hand held GPS for family positioning were used to conduct the investigation. The goodness - of - fit X^2 test for the binomial distribution and statistics Scan analysis were performed. Results A total of 215 people from 96 families in Dangchang county, gansu province were investigated in this study. Among them, 49 showed positive nested PCR detection results, with a positive rate of 22. 8% （49/215）. In the 96 families, 41 families showed positive nested PC R detection results, with a positive rate of 42.7 % （41/96）. X^2test and Scan analysis showed that the distribution of people infected with Leishmania corresponded to binomial distribution （P 〉 0. 05）. There was neither family aggregation, nor the spatial aggregation being observed. Conclusion The absence of familial aggregation and spatial aggregation might suggest that people infected with Leishmania randomly distributed in different families and regions. The high positive rate of nest PCR detection implicated that the transmission risk still existed. Sand fly control is the key point to control and prevent this disease in hill-type kala-azar endemic areas in Gansu.

关 键 词：山丘型黑热病 利什曼原虫 家庭聚集性 空间聚集性 甘肃 

分 类 号：R531.6[医药卫生—内科学]