2015-2017年南充市新生儿先天性甲状腺功能减低症发病情况调查分析  

Incidence of Congenital Hypothyroidism in Neonates in Nanchong From 2015 to 2017

作　　者：莫国梁[1] 张晓倩 张春艳 何永 雷霞[1] MO Guoliang;ZHANG Xiaoqian;ZHANG Chunyan;HE Yong;LEI Xia(Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Siehuan Province,China;The First Social Welfare Institnte of Nanchong City,Nanchong 637000,Siehuan Province,China.)

机构地区：[1]川北医学院附属医院,四川南充637000 [2]南充市第一社会福利院,四川南充637000

出　　处：《预防医学情报杂志》2018年第12期1521-1525,共5页Journal of Preventive Medicine Information

摘　　要：目的 探讨南充市2015-2017新生儿先天性甲状腺功能减低症（CH）发病情况,并分析影响CH的围产期相关因素。方法 收集2015-01/2017-12在南充市新生儿疾病筛查中心进行CH筛查的新生儿相关资料,根据是否患有CH将新生儿分为CH组和非CH组,并采用单因素分析及多元Logistic回归模型探讨新生儿CH发病的影响因素。结果 2015-2017年南充市共筛查345 342名新生儿,其中确诊CH 174例,CH总体发病率为50. 38/10万,且呈逐年增高趋势（χ^趋势2=16. 241,P〈0. 05）。单因素分析显示,病例组孕产妇高龄、合并妊娠期高血压、合并妊娠期糖尿病、合并甲状腺疾病、有甲状腺家族史等比例及新生儿出生胎龄不足37周或超过42周、出生体重低于2 500 g或超过4 000 g及以上、胎儿窘迫、新生儿感染、伴有其他出生缺陷比例和农村户籍比例均明显高于非CH组（P〈0. 05）。多元Logistic回归分析显示,孕产妇高龄、合并妊娠期糖尿病、合并甲状腺疾病、有甲状腺家族史及新生儿出生胎龄不足37周或超过42周、出生体重低于2 500g或超过4 000 g、胎儿窘迫、伴有其他出生缺陷等均是新生儿CH发病的危险因素（P〈0. 05）,而非农户籍是保护因素（P〈0. 05）。结论 2015-2017年南充市新生儿CH发病率呈逐年增高趋势;新生儿CH发病与孕产妇年龄、合并妊娠期糖尿病、合并甲状腺疾病、甲状腺家族史及新生儿出生胎龄、体重、胎儿窘迫等因素密切相关,应根据这些因素制定预防策略,以减少CH发病。Objective To investigate the incidence of congenital hypothyroidism （CH） in neonates in Nanchong between 2015 and 2017 and analyze related perinatal factors influencing CH. Methods The incidence of neonatal CH in the Neonatal Disease Screening Center of Nanchong from January 2015 to December 2017 was analyzed. Neonates were divided into a CH group and a no - CH group, and univariate analysis and multivariate Logistic regression analysis were performed to investigate the factors influencing incidence of CH in neonates. Results A total of 345 342 neonates were screened in Nanchong from 2015 to 2017, including 174 neonates diagnosed with CH. The overall incidence of CH was 50. 38/10^5, showing a yearly increasing trend 2 = X^2 trend 16.241, P 〈 0.05）. Univariate analysis showed that the proportions of pregnant and lying - in women of advanced age, women with gestational hypertension, gestational diabetes, thyroid diseases, familial history of thyroid diseases, neonates of gestational age 〈 37 weeks or 〉 42 weeks, neonates with birth weight 〈 2 500 g or ≥ 4 000 g, fetal distress, neonatal infections, neonates with other birth defects and rural household registration in the CH group were significantly higher than those in the no - CH group group （ P 〈 0.05 ）. Multivariate Logistic regression analysis showed that maternal advanced age, gestational diabetes, thyroid diseases and familial history of thyroid diseases, neonatal gestational age 〈37 weeks or 〉42 weeks, birth weight 〈2 500 g or~〉4 000 g, fetal distress and other birth defects were risk factors for the onset of CH in neonates （ P 〈 0.05 ）, while non - rural household registration was a protective factor （ P 〈 0.05 ）. Conclusion The incidence of CH in neonates in Nanchong was increasing year by year from 2015 to 2017. The incidence of CH in neonates is closely related to factors such as maternal age, gestational diabetes, thyroid diseases, family history of thyroid diseases, gestational age, weight and fetal distress. T

关 键 词：新生儿 先天性甲状腺功能减低症 围产期 影响因素 预防 

分 类 号：R181.3[医药卫生—流行病学]