七叶皂苷钠注射液对深静脉血栓患者内皮细胞功能及血清炎性因子的影响  

The Effect of Sodium Aescinate Injection in Treatment of deep Venous Thrombosis and both of the Function of Inflammtion and Endothelial cell

作　　者：董晓华 王莉萍 刘海平 DONG Xiao-hua;WANG Li-ping;LIU Hal-ping(Department of Cardiology;Department of Spine Surgery,Honghui Hospital,Xian Jiaotong University College of Medicine,Xian.710054,China)

机构地区：[1]西安交通大学医学院附属西安市红会医院心脏病科,西安710000 [2]西安交通大学医学院附属西安市红会医院脊椎外科,西安710000

出　　处：《血栓与止血学》2018年第4期580-583,共4页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的观察七叶皂苷钠注射液对深静脉血栓患者内皮细胞功能及血清炎性因子的影响。方法将2014年1月-2016年6月收治下肢深静脉血栓形成(DVT)患者72例,随机分为治疗组(36例)和对照组(36例),对照组给予尿激酶(UK)、低相对分子质量肝素(LMWH)、华法林治疗方案,治疗组在常规治疗基础上加用注射用七叶皂苷钠治疗。用药前后检查凝血酶原时间及活化部分凝血活酶时间、炎性因子、内皮细胞活化因子、血浆D二聚体水平和下肢深静脉彩超检查评价临床疗效。另设健康组36例。结果治疗组痊愈率33. 3%,总有效率90. 0%;对照组痊愈率25. 0%,总有效率75. 0%,疗效优于对照组(P <0. 01);治疗组及对照组治疗前凝血酶原时间(PT)及活化部分凝血活酶时间(aPTT)与健康组比较差异无统计学意义(P> 0. 05),血清白介素-6、8(IL-6、8),α肿瘤坏死因子(TNF-α),血浆内皮素-1(ET-1)、可溶性细胞间黏附分子-1(sICAM-1)、血管性血友病因子(vWF)及D二聚体均较健康组升高(P <0. 01);治疗组及对照组治疗后血清PT及aPTT较本组治疗前增加(P <0. 05),IL-6、ET-1等均较本组治疗前降低(P <0. 05),且治疗组降低更明显(P <0. 05)。结论七叶皂苷钠能提高急性下肢DVT治疗的总有效率,有效降低炎性因子的水平,改善内皮细胞功能。Objective To observe the effect of Sodium Aescinate Injection in treating acute lower extremity deep venous thrombosis （DVT）and its effect on serum inflammatory factorand, vascular endothelial cell. Methods 72 patients were performed who with lower extremity deep vein thrombosis, were randomly divided into treatment group（36 cases）and control group （36 eases）. The control group was given urokinase and low molecular weight heparin, warfarin for treating, and the treatment group were treated with Sodium Aeseinate Injection on the basis of routine treatment. Before and after treatment,platelet count,et al. and color Doppler ultrasound examination were evaluated. In the other 36 cases. Results The cure rate of treatment group was 33.3% ,the total efficiency of 90% ;the control group was 25% ,the total efficiency of 75% ,better than the control group（ P 〈 0.01 ）;the PT and aPTT of treatment group and control group before treatment were no significant than healthy group （P 〉 0.05 ） ; IL- 6, ET- 1, et al. and D- dimer were higher than that in normal group（P 〈 0.01 ） ;the treatment group and control group after treatment, serum PT and aPTT compared with the group before treatment increased （P 〈 0.05 ） , plasma levels of IL-6, ET-1, et al. were lower than those before the treatment（ P 〈 0.05 ）, and the treatment group decreased significantly （ P 〈 0.05 ）. Conclusion The total effective rate of the treatment of acute lower extremity DVT can be significantly improved by Sodium Aescinate Injection,and the levels of IL-6 ,ET-1, et al. were decreased.

关 键 词：深静脉血栓形成 七叶皂苷钠 内皮细胞 炎性因子 

分 类 号：R543.6[医药卫生—心血管疾病]