湖北恩施地区土家族人群CYP4F2基因多态性及血清硒含量与冠状动脉疾病的相关性  

Association of CYP4F2 gene polymorphisms and serum selenium levels with coronary artery disease in Tujia ethnic group in Enshi, Hubei

作　　者：王勇 王贤恩 黄浩 WANG Yong;WANG Xian＇en;HUANG Hao(Center of Cardiovascular Medicine,Central Hospital of Enshi Tujia and Miao Autonomous Prefecture,Enshi Hubei 445000,China)

机构地区：[1]恩施土家族苗族自治州中心医院心血管内科中心,湖北恩施445000

出　　处：《临床与病理杂志》2018年第10期2177-2182,共6页Journal of Clinical and Pathological Research

摘　　要：目的:探讨湖北恩施地区土家族人群C YP4F2基因多态性与冠状动脉疾病(coronar yar ter y disease,CAD)易感性的关系,以及血清硒水平与CYP4F2基因多态性在CAD发生中的交互作用。方法:采用成组病例-对照研究方法,选择湖北恩施地区土家族人群CAD患者100例,对照组人群100例,采用PCR检测CYP4F2基因多态性,氢化物发生原子荧光光谱法测定血清硒水平。结果:CAD组血清硒水平显著低于对照组;CYP4F2基因rs1558139与CAD风险无明显关系;r s 2 1 0 8 6 2 2多态性与C A D风险有明显关系,携带C C基因型的患者发生C A D的风险增加,此外CYP4F2基因rs1558135多态性与CAD风险有明显关系,rs3093135位点携带A等位基因者患CAD风险降低。血清硒水平低与CYP4F2 rs2108622 CC基因型者在CAD发生中有正交互作用。结论:湖北恩施土家族人群血清硒水平与CAD发生负相关;血清硒水平低与CYP4F2 rs2108622 CC基因型者之间存在协同作用,使CAD发生的危险性显著增加。Objective： To investigate the relationship between the polymorphism of CYP4 F2 gene and the susceptibility of coronary artery disease（CAD） in the Tujia population in Enshi, Hubei, and the interaction of serum selenium level and CYP4 F2 gene polymorphism in the occurrence of CAD. Methods： A total of 100 cases of CHD were selected from the Tujia population in Enshi, Hubei, and 100 healthy subjects cases were served as controls. The polymorphism of CYP4 F2 gene was detected by PCR, and the serum selenium level was measured by hydride generation atomic fluorescence spectrometry. Results： The serum selenium level in the CAD group was significantly lower than that in the control group; the CYP4 F2 gene rs1558139 was not significantly related to the risk of CAD, and the rs2108622 polymorphism was significantly related to the risk of CAD. The risk of CAD was increased in the patients carrying the CC genotype, and the rs1558135 polymorphism of CYP4 F2 gene was closely related to the risk of CAD. Patients with the rs3093135 gene carrying allele A had a lower risk of CAD. Low serum selenium level and CYP4 F2 rs2108622 CC genotype play a positive role in the occurrence of CAD. Conclusion： The serum selenium level is negatively correlated with CAD in Tujia ethic group in Enshi, Hubei, and there is a synergistic effect between the serum selenium level and the CYP4 F2 rs2108622 CC genotype, which significantly increases the risk of CAD.

关 键 词：CYP4F2 硒 冠状动脉疾病 

分 类 号：R543.3[医药卫生—心血管疾病]