中医针刺对缺氧缺血性脑损伤患儿智力发育迟缓及氧自由基的影响  

Effect of Acupuncture on Mental Retardation and Oxygen Free Radical in Children with Hypoxic-Ischemic Brain Damage

作　　者：张英英[1] 郭鑫[1] 单海军[1] 娄元俊[1] ZHANG Yingying;GUO Xin;SHAN Haijun;LOU Yuanjun(Rehabilitation Department for Children Brain Diseases,Henan Provinical Hospital of TCM,Zhengzhou 450002,Henan,China)

机构地区：[1]河南省中医院儿童脑病康复科

出　　处：《辽宁中医杂志》2018年第10期2171-2174,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：河南省高等学校重点科研项目计划(15A360003)

摘　　要：目的：研究中医针刺对缺氧缺血性脑损伤患儿智力发育迟缓及氧自由基的影响。方法：选取于2015年1月—2017年1月本院收治的60例缺氧缺血性脑损伤患儿作为本次研究对象,经数字随机表法分为观察组和对照组。两组均于入组后采用Bobath疗法进行康复训练;观察组在此基础上结合中医针刺进行治疗。观察记录两组患儿治疗后的临床疗效,比较两组患儿治疗前后ADL评分、GMQ评分及两组患儿随访6月DQ各能区得分。检测患儿治疗前后氧自由基指标超氧化物歧化酶（SOD）和丙二醛（MDA）在治疗前后水平变化。结果：观察组总有效率93. 33%明显大于对照组总有效率70. 00%,观察组临床疗效明显优于对照组（P 〈0. 05）。两组患儿血清中丙二醛（MDA）治疗后下降,而SOD水平则相对升高。观察组氧自由基水平改善情况明显优于对照组（P 〈0. 05）。患儿经治疗后的ADL评分和GMQ评分均呈上升趋势;观察组治疗后ADL评分、GMQ评分明显高于对照组（P 〈0. 05）。观察组患儿治疗后社会适应DQ、大运动DQ、精细运动DQ、言语DQ、个人社交DQ得分明显高于对照组（P 〈0. 05）。结论：中医针刺治疗缺氧缺血性脑损伤患儿疗效确切,能有效改善患儿智力发育迟缓状况及氧自由基水平。Objective： To study the effect of acupuncture on mental retardation and oxygen free radical in children with hypoxic-ischemic brain damage. Methods： From January 2015 to January 2017,60 patients with hypoxic-ischemic brain damage in our hospital were selected as the objects of this study. They were divided into the observation group and the control group by the digital random table method. The two groups were treated with Bobath therapy after entering the group,and the observation group was treated with acupuncture combined with Chinese medicine. The clinical efficacy of two groups of children after treatment was observed and compared. The scores of ADL and GMQ in two groups were compared before and after treatment,and the scores of DQ in the two groups were followed up for 6 months. The levels of oxygen free radical,superoxide dismutase（SOD） and malondialdehyde（MDA） were measured before and after treatment. Results： The total effective rate of the observation group was 93. 33%,significantly higher than that of the control group＇s 70%,and the clinical efficacy of the observation group was significantly better than that of the control group（P〈0.05）. Serum malondialdehyde（MDA） decreased in the two groups,while the level of SOD increased relatively. The improvement of oxygen free radical in the observation group was obviously better than that in the control group（P〈0.05）. The scores of ADL and GMQ after treatment showed an upward trend,and the scores of ADL and GMQ in the observation group were significantly higher than those in the control group（P〈0.05）. After treatment,the scores of social adaptation,DQ,big sport DQ,fine movement DQ,speech DQ and personal social DQ score of the observation group were significantly higher than those of the control group（P〈0.05）. Conclusion： Chinese medicine acupuncture treatment of hypoxic-ischemic brain damage in children has accurate effect,and can effectively improve the mental retardation and the level of oxygen free radicals in chi

关 键 词：中医针刺 缺氧缺血性脑损伤 智力发育 氧自由基 

分 类 号：R246.4[医药卫生—针灸推拿学]