河南省三市一般人群血浆中铜和锌分布特征及铜锌比值研究  

Distributional Characteristics of Copper and Zinc in Plasma and Cu/Zn Ratio in General Population of Three Cities in Henan Province

作　　者：武鑫 潘亚娟[2] 赵玮[2] 闫慧芳[2] WU Xin1;2;PAN Yajuan2;ZHAO Wei2;YAN Huifang2

机构地区：[1]北京市丰台区疾病预防控制中心 [2]中国疾病预防控制中心职业卫生与中毒控制所

出　　处：《环境卫生学杂志》2018年第5期412-418,共7页JOURNAL OF ENVIRONMENTAL HYGIENE

基　　金：国家科技支撑计划课题(2014BAI12B00;2006BAI06B00)

摘　　要：目的了解河南省三市一般人群血浆中铜、锌分布特征,并分析其分布特点。方法采取整群随机抽样的方法,于2009—2010年在河南省濮阳、焦作及平顶山3个城市的区县中,抽取了1 866名(6～60)岁人群作为调查对象,进行问卷调查及血液样品采集。应用电感耦合等离子体发射光谱法检测样品中铜、锌浓度,分析河南省三市一般人群血浆中铜、锌浓度在不同年龄、性别、地区的分布特征。结果调查对象血浆铜均数为933μg/L,中位数为923μg/L,P_(2.5)和P_(97.5)分别为612和1 355μg/L。男性血浆铜浓度低于女性,差别有统计学意义(P<0.01)。不同年龄组血浆铜差异有统计学意义(P<0.01),其中(46～60)岁年龄组最高(中位数1 003μg/L),(17～20)岁年龄组最低(中位数810μg/L);河南省濮阳、焦作和平顶山等三市一般人群血浆铜差异有统计学意义(P<0.01),其中焦作市最高(中位数933μg/L),平顶山市最低(中位数893μg/L)。调查对象血浆锌均数为878μg/L,中位数为859μg/L,P_(2.5)和P_(97.5)分别为618和1 217μg/L。男性血浆锌浓度高于女性(P<0.01);不同年龄组血浆锌差异有统计学意义(P<0.01),其中(21～30)岁年龄组最高(中位数934μg/L),(13～16)岁年龄组最低(中位数805μg/L);河南省濮阳、焦作和平顶山三市一般人群血浆锌中位数分别为887、884和801μg/L,差异有统计学意义(P<0.01)。不同性别、年龄、地区之间血浆铜锌比值均存在显著性差异(P<0.01)。结论河南省三市一般人群血浆铜、锌和铜锌比值在不同性别、年龄以及地区间均存在差异。Objectives To understand the distributional characteristics of copper and zinc in plasma of general population in three cities of Henan province. Methods A total of 1 866（6～60 year-old） subjects were selected by a cluster random sampling method in 2009-2010 from 3 cities of Henan province： Puyang, Jiaozuo and Pingdingshan. Questionnaire, and blood samples were collected. Copper and zinc levels in plasma were determined by inductively coupled plasma optical emission spectrometer（ICP-OES）. The distributional characteristics of copper and zinc in plasma in different age, gender and region groups in Henan Province were analyzed. Results The mean and median levels of plasma Cu were 933 and 923 μg/L, and the mean and median of P2.5 and P97.5 levels were 612 and 1 355 μg/L respectively. The levels of plasma copper in male was lower than that in female（P〈0.01）. Plasma copper was different in different age groups（P〈0.01）, it was the highest in（46～60） year-old group（median 1 003μg/L）, and it was the lowest in（17～20） year-old group（median 810 μg/L）; Plasma copper in Jiaozuo was the highest（median 933 μg/L） and that in Pingdingshan was the lowest（median 893 μg/L）, it was significantly different in three cities（P〈0.01）. The mean and median of plasma Zn were 878 and 859 μg/L, and the mean and median of P2.5 and P97.5 were 618 μg/L and 1 217 μg/L respectively. The level of plasma Zn was higher in male than that in female（P〈0.01）; Plasma zinc level was significantly different in different age groups（P〈0.01）, the highest was in（21～30） year-old group（median 934 μg/L）, and the lowest was in 13-16 year-old group（median 805 μg/L）; The median of plasma zinc in Puyang, Jiaozuo and Pingdingshan were 887, 884 and 801 μg/L, respectively, and the difference was statistically significant（P〈0.01）. Plasma Cu/Zn ratio was significantly different in different gender, age and region groups（P〈0.01）. Conclusions The level of plasma copper, z

关 键 词：一般人群 血浆 铜 锌 铜锌比值 

分 类 号：R126.8[医药卫生—环境卫生学]