193例药物性肝损伤的临床特点分析  

Clinical analysis of 193 cases with drug-induced liver injury

作　　者：夏玉朝[1] 黄领领[1] 陈洋 郭德洪[2] 李爽[1] XIA Yu-chao;HUANG Ling-ling;CHEN Yang;GUO De-hong;LI Shuang(aDepartment of Pharmac;bDepartment of Liver Disease,the Sixth People′s Hospital of Zhengzhou,Zhengzhou 450000,China)

机构地区：[1]郑州市第六人民医院药学部,郑州450000 [2]郑州市第六人民医院肝病科,郑州450000

出　　处：《临床药物治疗杂志》2018年第10期54-57,86,共5页Clinical Medication Journal

基　　金：郑州市科协(ZSYJJ15038)

摘　　要：目的:探讨药物性肝损伤(DILI)的临床特点,为临床防治DILI提供参考。方法:对某传染病医院2016年1月至2018年1月193例DILI进行回顾性调查,对DILI相关药物、临床表现、预后等进行分析。结果:引起DILI常见的药物有抗结核药、传统中药、抗菌药物、抗病毒药及抗肿瘤药。主要表现为肝功能指标异常和乏力、纳差、恶心、皮肤/巩膜黄染和皮肤瘙痒等。肝细胞损伤型最为常见(59.59%),DILI的严重程度与分型和药物类别有关联,DILI预后良好,好转和治愈率达91. 71%。结论:引起DILI的药物分布广泛,临床表现多样化;严重程度与分型有关联,及时治疗,大多预后良好。ObjectiveTo analyze the clinical characteristics of drug-induced liver injury（DILI）,and provide reference for clinical prevention and treatment of DILI.MethodsTotally 193 hospitalized cases with DILI between January 2016 to December 2018 were collected in ainfectious hospital. The DILI-related drugs, clinical manifestations and prognosis was analyzed.ResultsThe common drugs causing DILI included anti-tuberculosis drugs, Traditional Chinese Medicine, antibacterial agents, antiviral agents and antineoplastic agents.The main manifestations were abnormal liver function indicators, fatigue,poor appetite, nausea, skin/sclera yellow dye and itching.Hepatocyte injury type（59.59%） was the most common DILI type. The severity of DILI was associated with the classification of DILI and the type of drugs.The prognosis of DILI was good, and the improvement and cure rate was 91.71%.Conclusionthe drugs causing DILI are widely distributed and the clinical manifestations are diversified.Severityis associated with DILI type, and most of them have a good prognosis after timely treatment.

关 键 词：药物性肝损伤 临床特点 预后 

分 类 号：R969.3[医药卫生—药理学]