宝藿苷Ⅰ的制备方法及药理作用研究进展  

Preparation method and pharmacological effect of baohuoside Ⅰ

作　　者：李子豪[1] 柯仲成 封亮 贾晓斌[1,2] LI Zi-hao;KE Zhong-cheng;FENG Liang;JIA Xiao-bin(School of Pharmacy,Jiangsu University,Zhenjiang 212013,China;School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]江苏大学药学院,江苏镇江212013 [2]中国药科大学中药学院,江苏南京211198

出　　处：《中国中药杂志》2018年第17期3444-3450,共7页China Journal of Chinese Materia Medica

基　　金：国家“重大新药创制”科技重大专项(SQ2017ZX090301002)

摘　　要：淫羊藿为小檗科植物淫羊藿Epimedium brevicomu、箭叶淫羊藿E.sagittatum、柔毛淫羊藿E.pubescens或朝鲜淫羊藿E.koreanum的干燥叶,在我国有着几千年的用药历史,具有补肾阳、强筋骨、祛风湿等功效。现代研究表明宝藿苷Ⅰ在淫羊藿中含量较低,但却有着广泛的药理作用,如抗骨质疏松、抗肿瘤、改善认知功能障碍、脑缺血再灌注损伤保护、神经保护等。鉴于宝藿苷Ⅰ诸多的生物学活性及药理作用,对其制备方法和药理作用的研究越来越成为关注的热点。该文对近年来宝藿苷Ⅰ的制备方法及药理作用的相关研究进行了汇总和整理,为更好的大量制备宝藿苷Ⅰ及合理开发利用提供参考。Epimedii Folium,a famous traditional Chinese medicine made of dried leaves of Epimedium brevicomu,E. pubescens,E. sagittatum or E. koreanum,has been applied in China for several thousand years as a medicine. It has the function of reinforcing kidney Yang,strengthening muscles and bones and dispelling rheumatism. Modern studies have shown that baohuoside Ⅰ has a low content in Herba Epimedii,but it has a wide range of pharmacological effects,such as anti-osteoporosis,anti-tumor,improving cognitive dysfunction,cerebral ischemia-reperfusion injury protection,and neuroprotection. More and more attention has been paid to the preparation methods and pharmacological effects of baohuoside Ⅰ due to its many biological activities and pharmacological effects. In this present research,in order to provide references for the better mass preparation and rational exploitation of baohuoside Ⅰ,we summarized and sorted out the preparation methods and pharmacological effects of baohuoside Ⅰ which were published in recent years.

关 键 词：淫羊藿 宝藿苷Ⅰ 制备方法 药理作用 

分 类 号：R283[医药卫生—中药学] R285[医药卫生—中医学]