重组人碱性成纤维细胞生长因子治疗妇科难愈性创面的效果观察  

Clinical efficacy of rh-bFGF on gynecological refractory wounds

作　　者：范艳杰 李留霞[1] 郭瑞霞[1] 朱迎[1] Fan Yanjie;Li Liuxia;Guo Ruixia;Zhu Ying(Department of Gynecology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院妇科,450052

出　　处：《中国实用医刊》2018年第21期81-83,共3页Chinese Journal of Practical Medicine

摘　　要：目的 探讨外用重组人碱性成纤维细胞生长因子（rh-bFGF）治疗妇科难愈性创面的疗效.方法 选取2014年9月至2017年9月在郑州大学第一附属医院妇科住院手术后有难愈性创面患者46例,其中以术后应用rh-bFGF者23例作为观察组,以只进行常规消毒清洗创面的23例患者作为对照组.比较两组创面愈合率及创面愈合时间.结果 复查后1、2周,观察组与对照组阴道残端难愈性创面愈合率（18.75％比3.13％,93.75％比43.75％）比较差异有统计学意义（P均〈0.01）;观察组与对照组阴道残端难愈性创面愈合时间[（39.59±3.03）d比（45.34±2.98）d]比较差异有统计学意义（P〈0.01）.复查后1、2周,观察组与对照组人工阴道形成术创面愈合率（14.29％比0.00％,76.19％比28.57％）比较差异有统计学意义（P〈0.01）,观察组与对照组人工阴道形成术创面愈合时间[（41.19±3.43）d比（48.10±3.36）d]比较差异有统计学意义（P〈0.01）.结论 外用rh-bFGF治疗妇科难愈性创面愈合快,疗效显著.用药过程未发现对心、肝、肾等重要脏器损害及不良反应.Objective To investigate the curative effects of external recombinant human basic fibroblast growth factor （ rh-bFGF ） on gynecological refractory wounds .Methods Fourty-six patients who developed refractory wounds after operation in Department of Gynaecology of the First Affiliated Hospital of Zhengzhou University , from September 2014 to September 2018 , were selected as research objects.Among them, 23 patients who were treated with the rh-bFGF were allocated into observation group .Another 23 patients whose wounds were routinely disinfected and cleaned were selected as control group.Wound healing rate and remission time of the two groups were recorded and compared . Results At 1 week and 2 weeks after the review , there was a significant difference in the healing rate of refractory vaginal stump wound between observation group and contro group （ 18.75％vs.3.13％, 93.75％vs.43.75％） , P〈0.01; and there was a significant difference in remission time of refractory vaginal stump wound between observation group and control group [ （ 39.59 ±3.03 ） d vs.（ 45.34 ± 2.98）d], P〈0.01.At 1 week and 2 weeks after the review, the refractory wound healing rate of the vaginoplasty of observation group was statistically significant different from that of control group （14.29％vs.0.00％,76.19％vs.28.57％）, P〈0.01, and the wound remission time of observation group was statistically significant different from that of control group [ （ 41.19 ±3.43 ） d vs.（ 48.10 ± 3.36） d ] , P〈0.01.Conclusions rh-bFGF is conductive to remission of gynecological refractory wounds , with noticeable effect .No significant organ damage or adverse reactions to heart , liver and kidney is found during the medication .

关 键 词：重组人碱性成纤维细胞生长因子 难愈性创面 疗效 

分 类 号：R71[医药卫生—妇产科学]