小剂量酒石酸美托洛尔联合大剂量去乙酰毛花苷注射液治疗急性左心功能衰竭合并房颤30例临床观察  

Curative effects of low-dose metoprolol tartrate combined with high-dose deslanoside injection on acute left heart failure complicated with atrial fibrillation：an analysis of 30 cases

作　　者：于海东 Yu Haidong(Department of Cardiopulmonary,the Second People＇s Hospital of Datong,Datong 037005,China)

机构地区：[1]山西省大同市第二人民医院心肾内科,037005

出　　处：《中国实用医刊》2018年第21期92-95,共4页Chinese Journal of Practical Medicine

摘　　要：目的 研究小剂量酒石酸美托洛尔联合大剂量去乙酰毛花苷注射液治疗急性左心功能衰竭合并房颤的效果.方法 选取大同市第二人民医院2015年2月至2017年6月收治的60例急性左心功能衰竭合并房颤患者作为研究对象,按治疗方案分为对照组与观察组,每组30例.两组均给予常规治疗,对照组在常规治疗基础上加用大剂量去乙酰毛花苷注射液,观察组在对照组基础上加用小剂量酒石酸美托洛尔.比较两组治疗效果,治疗前后心室率、收缩压（SBP）、急性左心功能衰竭症状[呼吸频率、血氧饱和度（SpO2）]及其改善时间.结果 观察组总有效率为90.00％（27/30）,高于对照组的63.33％（19/30）,差异有统计学意义（P〈0.05）.治疗前,两组心室率比较差异未见统计学意义（P〉0.05）;治疗后0.5、1.0、1.5、2.0 h,观察组心室率低于对照组,差异有统计学意义（P〈0.05）.治疗前,两组SBP比较差异未见统计学意义（P〉0.05）;治疗后1.0、1.5、2.0 h,两组SBP较治疗前降低（P〈0.05）,但两组间比较差异未见统计学意义（P〉0.05）.治疗前,两组SpO2及呼吸频率比较差异未见统计学意义（P〉0.05）;治疗后2.0 h,观察组SpO2高于对照组,呼吸频率低于对照组（P〈0.05）.观察组急性左心功能衰竭症状缓解时间短于对照组（P〈0.05）.结论 小剂量酒石酸美托洛尔联合大剂量去乙酰毛花苷注射液治疗急性左心功能衰竭合并房颤,疗效显著,可有效控制心室率,加快急性左心功能衰竭症状缓解,还可一定程度降低血压水平.Objective To investigate the treatment effect of low-dose metoprolol tartrate combined with high-dose deslanoside injection on acute left heart failure complicated with atrial fibrillation.Methods A total of 60 patients with acute left heart failure and atrial fibrillation treated in the Second People＇s Hospital of Datong from February 2015 to June 2017 were selected as the research objects, and they were divided into control group and observation group according to the treatment protocols, with 30 cases in each group.All of patients in the two groups were treated by routine treatment, while patients in control group were treated with high-dose of deslanoside injection , additionally;and patients in observation group were treated with low-dose of metoprolol tartrate combined with high-dose of deslanoside injection .The treatment effect , ventricular rate , systolic blood pressure （ SBP） , acute left heart failure symptoms , including respiratory frequency and oxygen saturation （ SpO2 ） before and after treatment , and the improvement time of those symptoms were compared between the two groups.Results The total effective rate in observation group was 90.00％ （27/30）, which was higher than the 63.33％（ 19/30 ） in control group , and the difference was statistically significant （ P〈0.05 ） . Before treatment , there was no significant difference in ventricular rate between the two groups （ P〉0.05）;at 0.5, 1.0, 1.5 and 2.0 hours after treatment, the ventricular rate in observation group was lower than that in control group , and the difference was statistically significant （ P〈0.05 ） .Before＆nbsp;treatment, there was no significant difference in SBP between the two groups （P〉0.05）.At 1.0, 1.5 and 2.0 hours after treatment , the SBP in two groups decreased compared with those before treatment , and the difference was statistically significant （ P〈0.05） .But there was no significant difference in SBP at 0.5, 1.0, 1.5 and 2.0 hours between the two groups （P〉0.05）.

关 键 词：急性左心功能衰竭合并房颤 去乙酰毛花苷注射液 酒石酸美托洛尔 

分 类 号：R541.6[医药卫生—心血管疾病]