夏枯草胶囊联合左甲状腺素治疗结节性甲状腺肿的疗效观察  

Clinical observation of Xiakucao Capsules combined with levothyroxine in treatment of nodular goiter

作　　者：王路 张刚[1] WANG Lu;ZHANG Gang(Department of Nuclear Medicine,Second Hospital of Tianjin Medical University,Tianjin 300211,China)

机构地区：[1]天津医科大学第二医院核医学科,天津300211

出　　处：《现代药物与临床》2018年第11期2910-2913,共4页Drugs & Clinic

摘　　要：目的探究夏枯草胶囊联合左甲状腺素治疗结节性甲状腺肿的临床疗效。方法选取2015年1月—2018年1月天津医科大学第二医院收治的136例结节性甲状腺肿患者为研究对象,随机分为对照组和治疗组,每组各68例。对照组口服左甲状腺素钠片,100μg/次,1次/d。治疗组患者在对照组治疗基础上口服夏枯草胶囊,2粒/次,2次/d。两组均连续治疗30 d。观察两组的临床疗效,比较两组治疗前后甲状腺和甲状腺结节的最大直径、甲状腺激素水平的变化情况。结果治疗后,对照组和治疗组的总有效率分别是83.82%、94.12%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组甲状腺和甲状腺结节最大直径均较治疗前显著缩小,同组治疗前后比较差异有统计学意义(P<0.05);治疗后,治疗组甲状腺和甲状腺结节最大直径均显著小于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)均较治疗前显著降低,促甲状腺激素(TSH)显著升高,同组治疗前后比较差异有统计学意义(P<0.05);治疗后,治疗组FT3、FT4均显著低于对照组,TSH显著高于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,对照组和治疗组的总有效率分别是20.59%、7.35%,两组比较差异具有统计学意义(P<0.05)。结论夏枯草胶囊联合左甲腺素治疗结节性甲状腺肿具有较好的临床疗效,可显著缩小甲状腺和甲状腺结节的最大直径,改善甲状腺功能,具有一定的临床推广应用价值。Objective To investigate the efficacy of Xiakucao Capsules combined with levothyroxine in treatment of nodular goiter. Methods Patients（136 cases） with nodular goiter in Second Hospital of Tianjin Medical University from January 2015 to February 2018 were randomly divided into control（68 cases） and treatment（68 cases） groups. Patients in the control group were po administered with Levothyroxine Sodium Tablets, 100 μg/time, once daily. Patients in the treatment group were po administered with Xiakucao Capsules on the basis of the control group, 2 grains/time, twice daily. Patients in two groups were treated for 30 d. After treatment, the clinical efficacy was evaluated, and the changes thyroid and thyroid nodules maximum diameter, thyroid hormone levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment group were 83.82% and 94.12%, and there were differences between two groups（P〈0.05）. After treatment, the thyroid and thyroid nodules maximum diameter were significantly reduced, and there were differences in the same group（P〈0.05）. After treatment, the thyroid and thyroid nodules maximum diameter in the treatment group were smaller than those in the control group, and there were differences between two groups（P〈0.05）. After treatment, FT3, and FT4 were significantly decreased in two groups, but TSH was significantly increased, and there were differences in the same group（P〈0.05）. After treatment, FT3, and FT4 in the treatment group were lower than those in the control group, but TSH was higher than that in the control group, and there were differences between two groups（P〈0.05）. After treatment, the adverse reaction rates in the control and treatment group were 20.59% and 7.35%, and there were differences between two groups（P〈0.05）. Conclusion Xiakucao Capsules combined with levothyroxine has significant clinical effect in treatment of nodular goiter, can significantly reduce the maximu

关 键 词：夏枯草胶囊 左甲状腺素钠片 结节性甲状腺肿 甲状腺结节最大直径 游离三碘甲腺原氨酸 游离甲状腺素 促甲状腺激素 

分 类 号：R987[医药卫生—药品]