辅助孵化对卵胞浆内单精子注射妊娠结局的影响  

Impact of assisted hatching on the outcome of Intracytoplasmic sperm injection

作　　者：陶林林 李国臻 杨志伟 段新崇 耿亚松 TAO Lin-lin;LI Guo-zhen;YANG Zhi-wei;DUAN Xin-chong;GENG Ya-song(Infertility Specialist Hospitals/Xingtai Reproduction and Genetics Specialist Hospitals,Xingtai 05400)

机构地区：[1]邢台不孕不育专科医院,河北邢台054000

出　　处：《中国优生与遗传杂志》2018年第11期123-125,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨移植前辅助孵化技术(AH)对卵胞浆内单精子注射(ICSI)临床妊娠率及胚胎种植率的影响。方法回顾性分析了我院生殖中心2016年1月至2017年12月患者的共263个新鲜ICSI周期,女方年龄均<35岁。根据移植前是否进行辅助孵化分为辅助孵化组A组:AH组,非辅助孵化组B组:NAH组。比较两组对妊娠结局的影响。结果 A组(65.47%)的临床妊娠率显著高于B组(51.61%,P<0.05),种植率两组虽无统计学差异(P>0.05),但A组(42.51%)明显高于B组(36.09%)。两组的流产率和多胎率均没有显著差异(P>0.05)。结论移植前进行胚胎辅助孵化会显著提高<35岁卵胞浆内单精子注射周期的临床妊娠结局。Objective： To investigate the effect of the assisted hatching on the pregnancy rate and implantation rate. Methods：We retrospectively analyzed 263 fresh ICSI cycles of〈35 years from January 2016 to December 2017, The patients were placed in group A and group B, group A： AH group; group B： NAH group. The pregnancy outcome was compared between the two groups. Results： The pregnancy rate in group A （65.47%） was significantly higher than that in group B （51.61%, P〈0.05） , There was no significant difference of implantation rate in groups A （42.51%） and B （36.09%） , but it was higher in group A than in group 2 obviously. There were no significant differences in both the miscarriage rate and multiple pregnancies （P〉0.05） . Conclusion- The assisted hatching before embryo transfer for〈35 years patients can significantly improve the pregnancy outcome.

关 键 词：辅助孵化 卵胞浆内单精子注射 妊娠率 种植率 

分 类 号：R321-33[医药卫生—人体解剖和组织胚胎学]