肠道病毒71型衣壳蛋白VPl研究进展  

Study progress in capsid protein VP1 of enterovirus 71

作　　者：刘永娟[1] 周井义 赵绍林[3] 苗莉[4] 张春艳[3] 张婷[1] 霍娟[1] 杨自金[4] Liu Yongjuan;Zhou Jingyi;Zhao Shaolin;Miao Li;Zhang Chunyan;Zhang Ting;Huo Juan;Yang Zijin(Department of Central Laboratory,the First People＇s Hospital of Lianyungang,Lianyungang 222000,Jiangsu Province,Chin;Department of Anorectal Surgical,the First People＇s Hospital of Lianyungang,Lianyungang 222000,Jiangsu Province,China;Department of Clinical Laboratory,the First People＇s Hospital of Lianytmgang,Lianyungang 222000,Jiangsu Province,Chin;Department of Pediatrics Inter-hal Medicine,the First People＇s Hospital of Lianyungang,Lianyungang 222000,Jiangsu Province,China)

机构地区：[1]连云港市第一人民医院中心实验室,江苏连云港222000 [2]连云港市第一人民医院肛肠科,江苏连云港222000 [3]连云港市第一人民医院检验科,江苏连云港222000 [4]连云港市第一人民医院儿内科,江苏连云港222000

出　　处：《中华实用儿科临床杂志》2018年第22期1755-1758,共4页Chinese Journal of Applied Clinical Pediatrics

基　　金：江苏省自然科学基金（青年基金）（BK20180269）;连云港市科技局社会发展计划（sHl525）;连云港市第一人民医院青年英才豪森基金（QNl60204,QNl60103）;连云港市第一人民医院博士科研启动基金（BSl507）

摘　　要：人肠道病毒71型（enterovims 7l，EV71）是婴幼儿手足口病（hand，foot and mouth disease，HFMD）的主要致病原之一。临床研究发现，EV71感染可导致多种临床表现，从轻微HFMD到致命性脑干脑炎并发肺水肿甚至死亡，但原因尚不清楚。EV71衣壳蛋白VPl在病毒识别、结合、进入靶细胞及病毒颗粒装配过程中发挥核心作用，VPl变异是EV7l适应性和免疫原性的重要决定因素。现对VPl结构、功能及其相关的抗病毒疫苗和药物的研究进展进行综述，为进一步研发新的更有效的抗病毒疫苗和药物提供理论基础。Human enterovirus 71 （ EV71 ） is one of the major causative agent of hand, foot and mouth disease （HFMD） in infant. Chnical studies find that EV71 infection can cause a variety of clinical manifestations, from mild HFMD to fatal neurogenic pulmonary edema and even death, but the reasons remain unclear. The capsid protein VP1 of EV71 plays a key role in the processes of viral recognizing,binding and entering into the targeted cells and viral parti- cles assembling. VPI variation is a major determinant to EVT1 fitness and immunogenicity. This study reviews the re- search progress of the structure, functions and associated antiviral vaccines and drugs of VP1, which further provides a theoretical basis for developing new and more effective antiviral vaccine and drugs.

关 键 词：肠道病毒71型 手足口病 衣壳蛋白VP1 

分 类 号：R373.2[医药卫生—病原生物学]