青春期前肥胖与正常儿童尿促性腺激素和性激素水平的比较  

The comparison between prepubertal obesity and normal children's gonadotropin and gonadal steroid hormones in urine

作　　者：李楠楠 马亚萍 王永 陈春梅 杭飚 贲泽 杭胤 徐庄剑 LI Nannan;MA Yaping;WANG Yong;CHEN Chunmei;HANG Biao;BEN Ze;Hang Yin;XU Zhuangjian(Wuxi 4th People＇s Hospital/ The Affiliated Hospital of J iangnan University,Wuxi 214062,China;The Community Health Service Center of Mashan Street in Binhu District,Wuxi City,Wuxi 214091,China;The Community Health Service Center of Hudai Town in Binhu District,Wu.~i City,Wuxi 214161,China)

机构地区：[1]江南大学附属医院/无锡市第四人民医院,江苏无锡214062 [2]无锡市滨湖区马山街道社区卫生服务中心,江苏无锡214091 [3]无锡市滨湖区胡埭镇社区卫生服务中心,江苏无锡214161

出　　处：《扬州大学学报（农业与生命科学版）》2018年第3期37-45,共9页Journal of Yangzhou University：Agricultural and Life Science Edition

基　　金：江苏省妇幼健康科研项目(F201637);无锡市"科教强卫工程"建设项目(201619);无锡市卫生局妇幼保健科研项目(FYKY201404);无锡市卫生局科研项目(ME201411);无锡市卫生和计划生育委员会科研项目(ME201508);无锡市医院管理中心科研项目(YGZXM14015)

摘　　要：为测定青春期前肥胖儿童尿促性腺激素和性激素,留取无锡市2个社区3～7岁(无性征发育)肥胖和正常儿童晨尿,免疫化学发光法测定黄体生成素(LH)、卵泡刺激素(FSH)、雌三醇、雌二醇、睾酮和孕酮,比较青春期前肥胖与正常儿童尿促性腺激素和性激素水平。结果表明:肥胖男、女童、正常男、女童分别有119、67、568和556例。正常男童FSH随年龄的增长呈上升趋势,女童呈下降趋势,而肥胖男、女童则均无此趋势。男童肥胖组和正常组FSH、雌三醇、雌二醇和睾酮分别为56.68 (39.99～83.89)/48.18 (30.91～71.59)mU、2.309 (1.812～3.544)/1.956 (1.487～2.567)ng、2.878(2.166～3.750)/2.534(1.964～3.291)ng、13.71 (10.42～17.61)/10.40 (7.484～14.34)ng,2组P≤0.01;肥胖女童LH、FSH、雌三醇、雌二醇和孕酮与其正常组均无统计学差异。这一研究提示肥胖男童尿促性腺激素和性激素水平均高于其正常组,肥胖可能通过影响下丘脑-垂体-性腺轴功能而引起这一变化。By measuring urine gonadotropin and gonadal steroid hormones in prepubertal children,we aimed to compare the difference of gonadotropin and gonadal steroid hormones levels in urine between prepubertal obese and normal children.In two communities,the first morning voided urine samples were collected from prepubertal obese and normal children aged from 3 to 7 years old.Urine luteinizing hormone（LH）,follicle stimulating hormone（FSH）and gonadal steroid hormones（estriol,estradiol,testosterone and progesterone）were determined by immunochemiluminometric assay（ICMA）.Timed urine hormones contents were calculated and the results were showed as median（25 th-75 th percentile）.The results showed that there were 119,67,568 and 556 cases in obese boys,obese girls,normal boys and normal girls,respectively.With the age growing,there was an increasing trend for FSH among normal boys,and there was a declining trend among normal girls,while there was no significant trend among obese boys（or girls）.The FSH,estriol,estradiol and testosterone in obese boys were respectively 56.68（39.99-83.89）mU,2.309（1.812-3.544）ng,2.878（2.166-3.750）ng and 13.71（10.42-17.61）ng,and for normal boys were respectively 48.18（30.91-71.59）U,1.956（1.487-2.567）ng,2.534（1.964-3.291）ng and 10.40（7.484-14.34）ng,and there were significant differences for the same indicator between two obese and normal boys（all P≤0.01）.However,there were no significantdifferences in FSH,estriol,estradiol and progesterone between obese and normal girls.The levels of urine gonadotropin and gonadal steroid hormones in obese boy were higher than those in normal boy;obesity may contribute to this difference through affecting the function of HPGA.

关 键 词：青春期前儿童 肥胖 尿促性腺激素 尿性激素 免疫化学发光法 

分 类 号：R179[医药卫生—妇幼卫生保健] R723.14[医药卫生—公共卫生与预防医学]