瑞芬太尼联合丙泊酚用于脑出血患者手术麻醉的疗效分析  

Efficacy analysis of remifentanil combined with propofol in patients with cerebral hemorrhage

作　　者：任俏[1] 鲁爱民[1] 王开俊[1] 王向宇 徐海峰 REN Qiao;LU Aimin;WANG Kaijun;WANG Xiangyu;and XU Haifeng(Department of Anesthesiology,Luohu People＇s Hospital,Shenzhen 518052,China)

机构地区：[1]广东省深圳市罗湖区人民医院麻醉科,518052

出　　处：《中华灾害救援医学》2018年第12期679-682,共4页Chinese Journal of Disaster Medicine

摘　　要：目的探讨瑞芬太尼联合丙泊酚用于脑出血患者手术麻醉中的效果,为临床提供参考。方法选取2016-01至2017-12深圳市罗湖区人民医院麻醉科收治的脑出血手术患者90例为研究对象,采用密闭信封并按照计算机随机数表法分为对照组(n=45)和试验组(n=45)。对照组给予芬太尼联合丙泊酚麻醉,试验组给予瑞芬太尼联合丙泊酚麻醉,对比观察两组患者的麻醉效果。结果试验组患者术中血压平均值明显优于对照组(t=7.47,P<0.001);术后自主呼吸恢复时间和意识清醒时间明显早于对照组(t=3.85,P=0.001;t=3.37,P=0.001);丙泊酚用量、心律失常和麻醉不良反应发生例数少于对照组(P<0.05),差异具有统计学意义。结论对于脑出血手术患者,选择瑞芬太尼联合丙泊酚的麻醉方法,可以更好地控制患者的血压,缩短患者苏醒时间,同时也可以减少丙泊酚的用量,减少麻醉不良反应的发生,可以为临床麻醉提供借鉴参考。Objective The objective of this study was to investigate the efficacy of remifentanil combined with propofol in patients with cerebral hemorrhage, and to provide clinical basis. Methods A total of 90 cases of cerebral hemorrhage treated in department of anesthesiology, Luohu District People＇s Hospital from January 2016 to December 2017 were selected and randomly divided into control group （n=45） and test group （n=45） using sealed envelopes and computer random number table method. The control group was given fentanyl combined with propofol anesthesia, while the test group with treated by remifentanil combined with propofol anesthesia. The anesthetic efficacy of the two groups was compared. Results The mean blood pressure in the test group was significantly higher than that in the control group （t=7.47,P〈0.001）; the time of spontaneous respiratory recovery and returning to consciousness in the test group were significantly earlier than those in the control group （t=3.85,P=0.001; t=3.37,P=0.001）; the incidence of adverse events relating to dosage of propofol, arrhythmia and anesthesia in the test group were less than those in the control group, and the differences were statistically significant （P〈0.05）. Conclusions The anesthesia of remifentanil combined with propofol for patients undergoing cerebral hemorrhage surgery can better control the blood pressure and shorten the recovery time. Moreover, it is also capable of reducing the dosage of propofol and the incidence of adverse reactions of anesthesia. This provides reference for clinical anaesthesia.

关 键 词：瑞芬太尼 丙泊酚 脑出血 麻醉 

分 类 号：R614.24[医药卫生—麻醉学]