蚕丝蛋白用作胶囊壳材料的研究  

Study on silk protein used as capsule shell material

作　　者：刘凯 匡大江 王诗怡 付华[1] 王垠龙 卢神州[1,2] LIU Kai;KUANG Dajiang;WANG Shiyi;FU Hua;WANG Yinlong;LU Shenzhou(College of Textile and Clothing Engineering;National Engineering Laboratory for Modern Silk,Soochow University,Suzhou 215123,China)

机构地区：[1]苏州大学纺织与服装工程学院,江苏苏州215123 [2]苏州大学现代丝绸国家工程实验室,江苏苏州215123

出　　处：《丝绸》2018年第12期6-12,共7页Journal of Silk

基　　金：江苏省自然科学基金项目(BK20171239);江苏省高校自然科学研究重大项目(15KJA540001)

摘　　要：当前,市场上胶囊的主要制作原料是明胶,由于明胶胶囊价格昂贵,并且具有低溶解性所导致的药效不能有效发挥的缺点,因此寻找替代材料刻不容缓。文章采用蚕丝蛋白来替代明胶,研究不同配比丝素丝胶制备的胶囊壳复合材料的结构特性。通过加入脯氨酸、甲酰胺、乙二醇来调节材料在模拟胃液、肠液中的崩解时间,测定细胞培养检测材料的细胞相容性等。结果表明,随着丝胶含量的提高,复合材料容易在胃液中崩解,而随着丝素含量提高,材料不易在胃液浸泡下崩解,但可以在肠液中崩解。利用结构调节剂可以期望获得某些用于胃、肠胶囊壳的新型材料。At present, the main raw material for capsule production on the market is gelatin. Since gelatin capsules are expensive and have the disadvantage of low solubility which causes that the drug effect cannot be effectively exerted. Thus, it is imperative to find alternative materials. In this paper, silk fibroin （SF） was used as a substitute for gelatin, and structural properties of capsule shell composites prepared with different ratio of silk fibroin and sericin were studied. The disintegration time of the material in the simulated gastric juice and intestinal fluid was adjusted by adding proline, formamide, and ethylene glycol, and the cell compatibility of the material was detected by cell culture. The results showed that with the increase of sericin content, the material was easy to disintegrate in gastric juice. With the increase of silk fibroin content, the material was not easy to disintegrate in gastric juice immersion,but disintegrated in intestinal juice. Some new materials for the production of gastro-intestinal capsule shells can be expected to be obtained by using structural regulators.

关 键 词：丝素 丝胶 胶囊 崩解 细胞相容性 

分 类 号：TS102.54[轻工技术与工程—纺织工程] TB383[轻工技术与工程—纺织科学与工程]