复方清肺泡腾片质量标准研究  

Quality Standard of Fufangqingfei Effervescent Tablets

作　　者：谭栀恩 罗毅 刘灵杰[1] 傅鹏[1] 李媛 黄俊善 陈卫卫[1] Zhien;Luo Yi;Liu Lingjie;Li Yuan;Huang Junshan;Chen Weiwei(Guangxi University of Traditional Chinese Medicine,Nanning 530001;International Zhuang Medical Hospital of Guangxi,Nanning 530001;Guangxi Science and Technology Press,Nanning 530022;Faculty of Chinese Medicine Science Guangxi University of Chinese Medicine,Nanning,530001)

机构地区：[1]广西中医药大学,南宁530200 [2]广西国际壮医医院,南宁530001 [3]广西科学技术出版社有限公司,南宁530022 [4]广西中医药大学赛恩斯新医药学院,南宁530001

出　　处：《壮瑶药研究季刊》2018年第2期56-65,共10页Research of Zhuang and Yao Ethnic Medicine

基　　金：广西壮瑶药协同创新中心-复方清肺泡腾片的研制(zyxt[2015]-02);壮瑶药协同创新中心(桂教科研[2013]20号);广西壮瑶药重点实验室(桂科基字[2014]32号);广西重点学科壮药学(桂教科研[2013]16号);八桂学者中药创新理论与药效研究;广西中药制剂共性技术研发重点实验室(ZJGX2016011)

摘　　要：目的：建立复方清肺泡腾片质量标准。方法：采用薄层色谱法（TLC）对方中百合、罗汉果进行定性鉴别，采用高效液相色谱法（HPLC）测定制剂中橙皮苷、绿原酸含量。结果：TLC法可检出百合、罗汉果薄层色谱斑点清晰，阴性对照无干扰，专属性强。橙皮苷在1．024-8．198tzg范围内呈良好线性关系，平均回收率为98．91％，RSD为1．72％。绿原酸在1．008-8．064μg范围内呈良好线性关系，平均回收率为97．24％，RSD为1．48％。结论：方法可靠、准确、专属性强，可用于复方清肺泡腾片的质量控制。Objective： To establish the quality standard for Qingfei effervescent tablets. Methods： Lilium lancifolium Thunb and hesperidin and chlorogenic acid Siraitia grosvenorii （Swingle） were identified by TLC. The contents of were determined by HPLC. Results： The Lilium lancifolium Thunb and Siraitia grosvenorii （Swingle） could be identified by TLC. The injection weights of hesperidin and chlorogenic acid were in a good linearity over the ranges of 1. 024-8. 198 μg, 1. 008-8. 064 μg; and theaverage recoveries of hesperidin and chlorogenic acid were 98.91% and 97.24% with RSD of 1.72 and 1.48%, respectively. Conclusion： The method is reliable, accurate, specific, and can be used for quality control of the Qingfei effervescent tablets.

关 键 词：复方清肺泡腾片 薄层色谱 高效液相色谱 质量标准 

分 类 号：R286.0[医药卫生—中药学]