千金苇茎汤联合可必特、氨溴索雾化吸入对老年慢性阻塞性肺疾病急性加重期的临床观察  

Therapeutic effects of Qianjinweijing decoction combined with atomization inhalation of combivent and ambroxol on acute exacerbation of senile chronic obstructive pulmonary disease

作　　者：号素然 武巧玲 曹雪玲 HAO Suran;WU Qiaoling;CAO Xueling(Department of Internal Medicine,People＇s Hospital of Zhengding County,Hebei,Zhengding 050800,China)

机构地区：[1]河北省正定县人民医院内科,050800 [2]河北省正定县人民医院护理部,050800

出　　处：《河北医药》2018年第24期3708-3711,共4页Hebei Medical Journal

基　　金：石家庄市科学技术研究与发展计划项目(编号:171461783)

摘　　要：目的探讨千金苇茎汤联合可必特、氨溴索雾化吸入治疗对老年慢性阻塞性肺疾病急性加重期的相关实验室指标的影响,进一步评价其临床疗效性及安全性。方法选取2015年5月至2017年5月就诊的120例老年慢性阻塞性肺疾病的患者,根据患者的治疗意愿,将其平均分为对照组和研究组,每组60例,对照组给予患者可必特联合氨溴索雾化吸入治疗,研究组在对照组的基础上给予千金苇茎汤口服,2组的治疗周期均为15 d,治疗结束后观察比较2组患者的肺功能,降钙素原(PCT)、C-反应蛋白(CRP),肺部体征、胸片、周围血象恢复时间,焦虑自评量表(SAS)、抑郁自评量(SDS)评分,临床疗效以及不良反应发生率。结果治疗前2组患者的年龄,性别,病程,PCT,CRP,肺功能,SAS、SDS评分比较差异无统计学意义(P> 0. 05)。治疗后2组患者的PCT、CRP、肺功能、周围血象恢复时间、SAS、SDS评分较前明显改善,差异有统计学意义(P <0. 01);且治疗后2组患者的PCT,CRP,肺功能,周围血象恢复时间、SAS、SDS评分、临床疗效均明显优于对照组,差异有统计学意义(P <0. 05,P <0. 01); 2组患者的不良反应发生率比较差异无统计学意义(P> 0. 05)。结论千金苇茎汤联合可必特、氨溴索雾化吸入治疗对老年慢阻肺急性加重期的PCT、CRP、肺功能有明显的改善作用,且治疗后研究组的临床疗效、中医证候疗效显著,无明显不良事件的发生,安全性佳,为老年慢阻肺患者生活质量的保障保驾护航,值得临床中进一步推广应用。Objective To investigate the effects of Qianjinweijing decoction combined with atomization inhalation of combivent and ambroxol on related related laboratory indexes in elderly patients with chronic obstructive pulmonary disease （COPD） at acute exacerbation period, and to evaluate its clinical therapeutic effects and safety. Methods A total of 120 elderly patients with COPD at acute exacerbation period who were teeated in our hospital from May 2015 to May 2017 were enrolled in the study. According to the treatment wishes of patients, these patients were divided into control group （n = 60 ） and observation group （ n = 60 ）. The patients in control group were treated by atomization inhalation of combivent and ambroxol,however,the patients in observation group, on the basis of control group,were treated by Qianjinweijing decoction, with a treatment course of 15 days for both groups. After treatment, the lung function, calcitonin original （PCT）, C-reactive protein （CRP）, pulmonary symptoms, chest X-ray, peripheral blood picture recovery time, self-evaluation of anxiety scale （SAS） ,depression self assessment （SDS） score, clinical efficacy and the incidence of adverse reactions were observed and compared helween the lwo groups. Results Before treatment, there were no significant differences in patient＇ s age and gender, course of disease,PCT, CRP,lung function, SAS and SDS scores between the two groups （P 〉 0.05）. After treatment the PCT,CRP,lung function, peripheral blood image recovery- time, SAS and SDS scores were significantly improved in both groups,as compared with those before treatment （P 〈 0.01 ） , moreover, the PCT, C RP, pulmonary- function, peripheral blood index recovery- time, SAS and SDS scores, clinical curative effects in observation group were superior to those in control group （ P 〈 0.05 or P 〈 0.01 ）. In addition there was no significant difference in the incidence of adverse reactions between the two groups （P 〉 0. 05 ）. Conclusion The Qianj

关 键 词：千金苇茎汤 可必特 氨溴索 雾化吸入 老年慢阻肺急性加重期 临床观察 

分 类 号：R563[医药卫生—呼吸系统]