大孔交联聚甲基丙烯酸羟乙酯树脂的制备及其结构性能  

Synthesis, Structure and Properties of Macroporous Crosslinked Poly(2-hydroxyethyl methacrylate) Resins

作　　者：卢玲[1] 石可喻[1] 袁直[1] 何炳林[1] 

机构地区：[1]南开大学高分子化学研究所吸附分离功能高分子材料国家重点实验室,天津300071

出　　处：《应用化学》2002年第9期817-821,共5页Chinese Journal of Applied Chemistry

基　　金：国家 973计划资助项目 (G19990 64 70 7)

摘　　要：采用甲基丙烯酸羟乙酯 (HEMA)为单体 ,双甲基丙烯酸乙二醇酯 (EGDMA)为交联剂 ,以乙酸乙酯或乙酸乙酯与十二醇的混合物为致孔剂 ,通过水相悬浮聚合制备了一系列大孔交联聚甲基丙烯酸羟乙酯(PHEMA)树脂 ,并对其孔结构、性能进行了研究 ,讨论了交联剂用量和致孔剂种类、用量、组成等对 PHEMA树脂的孔分布、比表面积、孔容等的影响。结果表明 ,以乙酸乙酯为致孔剂时得到的孔分布较宽 ,而采用混合致孔剂时 ,孔分布较窄 ,可得到 1 0 0 0 nm左右的大孔 ;随致孔剂总用量和十二醇含量的增加 ,孔容增大而比表面减小 ;PHEMA树脂在溶度参数为 1 4.5～ 1 0 .Macroporous crosslingked poly(2 hydroxyethyl methacrylate)(PHEMA) beads were prepared via a suspension polymerization technique by reacting 2 hydroxyethyl methacrylate(HEMA) with ethyleneglycol dimethylacrylate(EGDMA) as crosslinking agent as well as ethyl acetate or mixture of ethyl acetate and dodecanol as porogenic agent. The effects of amount of crosslinking agent, kind, amount and composition of porogenic agent on the pore distribution, specific surface area and pore volume of PHEMA beads were investigated. It was found that the pore distribution of resin with ethyl acetate as porogenic agent was broader than that with mixed agents. The pore volume was found increased with increase in total amount of mixed porogenic agent and the amount of dodecanol, while specific surface area decreased. PHEMA resins have good swelling ability in common solvents with solubility parameters from 14 5 to 10 0.

关 键 词：大孔交联聚甲基丙烯酸羟乙酯树脂 甲基丙烯酸羟乙酯 双甲基丙烯酸乙二醇酯 孔结构 血液净化疗法 吸附剂载体 

分 类 号：R457[医药卫生—治疗学] TQ425.23[医药卫生—临床医学]