5-阿维菌素B_(1a)酯的合成及生物活性  

Synthesis and Bioactivity of 5-Avermectin B_(1a) Esters

作　　者：廖联安[1] 李正名[2] 方红云[1] 赵卫光[2] 陈明德[1] 范志金[2] 刘桂龙[2] 

机构地区：[1]厦门大学化学系,厦门361005 [2]南开大学元素有机化学研究所元素有机化学国家重点实验室,天津300071

出　　处：《高等学校化学学报》2002年第9期1709-1714,共6页Chemical Journal of Chinese Universities

基　　金：国家自然科学重点基金 (批准号 :2 983 2 0 5 0 )资助

摘　　要：阿维菌素 B1 a(AVB1 a)与羧酸在 DMAP/DCC体系中直接酯化 ,得到 1 0个 5 -AVB1 a酯衍生物 ,产率5 0 %～ 79% ;其化学结构由 IR,1 H NMR,1 3C NMR和 MS谱确证 .生物活性测定结果表明 ,部分 5 -阿维菌素 B1 a酯衍生物具有良好的杀虫。Ten 5 Avermectin B 1a ester derivatives were prepared from avermectin B 1a and carboxylic acids in the systems of DCC/DMAP. Their chemical structures were confirmed by IR, 1H NMR, \{ 13 C NMR\} and MS. Their insecticidal activity was evaluated against Aphis gossypii Glover and Tetranychus truncatus Ehara. It was found that some compounds showed a higher insecticidal activity than Avermectin.

关 键 词：5-阿维菌素B1a酯 合成 生物活性 酯化 DMAP/DCC 杀虫活性 杀螨活性 

分 类 号：TQ453.2[化学工程—农药化工] TQ454.2