分子印迹聚合物及其在有机合成中的应用  

Molecularly imprinted polymer and its application in organic synthesis

作　　者：袁小亚[1] 余响林[1] 黄锦霞[1] 

机构地区：[1]湖北大学高分子材料湖北省重点实验室,湖北武汉430062

出　　处：《湖北大学学报（自然科学版）》2002年第3期250-255,266,共7页Journal of Hubei University：Natural Science

基　　金：国家自然科学基金(29872012)

摘　　要：分子印迹技术是近年发展起来的一种新颖的有机合成手段。评述了分子印迹聚合物的制备方法及尚有待深入的关键问题,重点介绍了分子印迹聚合物用作催化剂在有机合成中应用的优势及研究近况,特别是用作手性催化剂不对称合成光学活性物质。并设计将分子印迹聚合物用于催化醛酮不对称还原反应,可获得较高光学产率的手性醇,其％e.e值达95％以上。Molecular imprinting is a novelly organic synthetic technology developed in recent yeas.This review describes the preparation of molecularly imprinted polymer(MIP) and the critical problems to be fiirthur explored, and emphasises on the introduction of MIP's superiority of its application in the field of organic synthesis as a catalyst and the present research, especially about its use as the chiral catalyst during the synthesis of optically - activated reagents . MIP is designed to asymmetrically catalysize the reducing - reaction of the aldehydes or ketones and the higher optical yields of chiral alcohols can be obtained with the value of % e. e over 95 % .

关 键 词：分子印迹聚合物 手性催化剂 不对称有机合成 模拟酶催化剂 制备方法 光学产率 

分 类 号：O643.36[理学—物理化学] O621.3[理学—化学]