不同晶型氧化铝对肺巨噬细胞表面形态的影响  

Effects of Aluminum Oxide in Different Crystal on Morphology of Alveolar Macrophage Surface

作　　者：陈莉[1] 富博[1] 赵秀清[1] 章吉芳 杨美玉[1] 

机构地区：[1]沈阳市劳动卫生职业病研究所,沈阳110024

出　　处：《中华劳动卫生职业病杂志》1991年第2期78-81,共4页Chinese Journal of Industrial Hygiene and Occupational Diseases

摘　　要：本文利用肺巨噬细胞体外培养和扫描电镜观察方法,研究了γ,α两种晶型氧化铝和石英粉尘对豚鼠肺巨噬细胞膜表面形态的影响。结果表明两种晶型氧化铝均具细胞毒性,与石英相比,氧化铝巨噬细胞膜改变出现较迟,主要表现为膜内凹、皱褶增宽增大,泡状结构、丝状伪足和细胞表面光滑、皱缩。γ型氧化铝对细胞损害作用强于α型氧化铝。A Scanning electron microscopic study of the in vitro effects ofquartz,γ-aluminum oxide,and α-aluminum oxide on guinea pig alveolarmacrophage surface was undertaken.Results showed that both forms of alu-minum oxide have cytotoxic effects.The change of cell membrane treated withaluminum oxide occured later than that with quartz dust by the appearance ofindentation,larger ruffle,bleblike structure,filopodia,and as the time of dustexposure increases,displayed a smooth surface,pyknosis.γ-Aluminum oxidedust caused more severe injury to macrophage than the α-form.

关 键 词：粉尘 氧化铝 肺巨噬细胞 表面形态 

分 类 号：R598.202[医药卫生—内科学]