苯乙烯生物监测指标的研究  

Study on biological monitoring of styrene

作　　者：倪莉珍 陈楚良[1] 金锡鹏[1] 

机构地区：[1]上海医科大学公共卫生学院,200032

出　　处：《中华劳动卫生职业病杂志》1991年第3期129-131,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

摘　　要：本文调查了玻璃钢厂生产车间27名苯乙烯接触者。接触时间加权平均浓度为3.9-750mg/m^3,接触时间90分钟。采用Hplc法分离测定尿中苯乙烯的代谢物苯酰甲酸和扁桃酸。用浓缩热解吸法测定肺泡气中的苯乙烯。结果表明尿代谢物浓度及肺泡气浓度不仅班前与班后有极显著差别,且分别与接触水平呈良好的相关。尿代谢物排泄动力学研究表明:扁桃酸排泄符合药物动力学二室模型,生物半减期快速相T_1/2~α=2.9小时;慢速相T_(1/2)β=23.8小时。尿中苯酰甲酸的排泄与药物动力学一室模型相符T^(1/2)=15小时。27 Workers occupationally exposed to styrene vapour wereinvestigated.The concentrations of exposure (TWA-90 mins) was3.9mg-750mg/m^3.The styrene in alveolar air and the major metabolites inurine,phenylglyoxlic and mandelic acid,were determined at the prework andthe end of shift.The results showed that the concentrations of alveolar air andurinary metabolites presented good relationships to the exposureintensity.Urinary metabolite mandelic acid was cleared according to a lineartwo-compartment pharmacokinetic model.Its T(1/2)α=2.9h and T(1/2)β=23.8hrespectively.The pharmacokinetic profile of phenylglyoxlic acid correspondedto a single compartment model.The T_(1/2)=15hr.

关 键 词：苯乙烯 生物监测 指标 

分 类 号：R134.1[医药卫生—劳动卫生]