喹胺酸对急性铍中毒大鼠肝功能的保护作用  

Protective Effect of Ouinamidic Acid on Liver function in Acute Beryllium (Be) Poisoned Rats

作　　者：王文学[1] 王又兰[1] 陈寿芳 王家华[2] 

机构地区：[1]北京医科大学第三医院职业病研究中心 [2]北京医科大学三院检验科

出　　处：《中华劳动卫生职业病杂志》1991年第3期141-143,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

摘　　要：49只Wistar大鼠分成4组:对照组、中毒组、治疗组Ⅰ(治疗1天)和治疗Ⅱ(治疗3天)。大鼠由静脉注入BeSO_4·4H_2O 7.50mg/kg,即刻由腹腔注入喹胺酸500mg/kg者为治疗组;腹腔注入生理盐水者为中毒组。对照组均注射生理盐水。结果如下:对照组SGPT40u/L左右渡动,尿铍、肝铍和肾镀均阴性。中毒组于染毒后第三天尿铍总排泄量为染毒量的9.3%,此时SGPT活性高达1600u/L;肝铍含量29.1μg。而同时期治疗组Ⅰ和Ⅱ尿铍总排出量分别为25.4%和27.0%;SGPT活性分别为60u/L和52u/L;肝铍含量分别为17.4μg和16.2μg。以上中毒组和治疗组间各指标比较均有显著性差异(P<0.05或P<0.01)。本实验结果表明喹胺酸对急性铍中毒大鼠的肝功能有明显的保护作用。Forty-nine rats were divided randomly into four groups.BeSO_4·4H_2O7.5mg/kg was injected (iv) into each rat of the three groups.Afterintoxication,rats of treated group 1 were injected (ip) with Quinamidic Acid(QA) 500mg/kg immediately,grorp 2 were injected (ip) with 500mg/kg ofQA each day for 3 days,group 3 received normal saline,as the untreated pois-oned gruop,and group 4 were given with normal saline instead of BeSO_4·4H_2O and QA as control. Results of the test showed that the activity of SGPT fluctuats arround 40U/L in the control group 4 and the Be contents in urine,liver and kidney wasundetectable.The activity of SGPT of toxic group 3 was up to 1600 U/L butthe treated groups (1 and 2) were 60 U/L and 52 U/L respectively(P<0.01).The liver Be of toxic group was obviously higher than that of treatedgroups (P<0.05),and the urine Be was apparenty lower than treated groups(P<0.05).These results showed that QA obviously protected liver function onacute beryllium poisoning rats.

关 键 词：喹胺酸 铍中毒 肝功能 保护 

分 类 号：R598.105[医药卫生—内科学]