氯丁二烯对男性生殖影响的流行病学研究  

Epidemiological Study on the Effect of Chloroprene on Male Reproduction

作　　者：席力强 蔡世雄[1] 黄美媛[1] 李卫[2] 吴维皑[1] 陈曙旸[1] 张作文[1] 郭景珍 苏江[1] 

机构地区：[1]中国预防医学科学院劳动卫生与职业病研究所 [2]中国预防医学科学院统计室

出　　处：《中华劳动卫生职业病杂志》1991年第4期202-205,共4页Chinese Journal of Industrial Hygiene and Occupational Diseases

摘　　要：对1446名接触氯丁二烯男工和1127名对照男工的生殖结局进行了回顾性队列研究。使用SAS程序包,采用X^2检验和非条件Logistic回归分析方法,结果表明,氯丁二烯作业男工妻子的自然流产发生率(5.52%)显著高于对照组(3.52%),P<0.01。控制混杂因素后的相对危险度为1.29,95%可信限为1.09～1.53。其自然流产率的显著增高主要表现于早期自然流产率的显著增高。但本研究未发现男工接触氯丁二烯能使不孕、过期产、早产、死产、低体重儿、新生儿死亡和围产儿死亡等的发生率显著增高。A retrospective cohort study on the reproduction of 1446 male workers ex-posed to chloroprene vs 1126 non-exposed workers was carried cut,Resultswere analysed by SAS.X^2 tests and non-conditional Logistic regression wereused.Spontaneous abortion occurred in 5.52% of wives of exposed male work-ers vs 3.52% in control (P<0.01).After controlling confounders RR=1.29(95% Cl:1.09—1.53).Spontaneous abortions in exposed group mainly oc-curred in the first trimester of pregnancy.Other parameters of reproductivedamage,such as infertility,premature delivery,congenitalmalformation,infant death,etc.also studied.

关 键 词：氯丁二烯 男性 生殖损伤 流行病学 

分 类 号：R598.1[医药卫生—内科学]