慢性特发性血小板减少性紫癜患者PAIgG、ACAIgG的测定及意义  

The detection of blood PAIgG and ACAIgG in chronic idiopathic thrombocytpenic purpura

作　　者：徐成伟[1] 卢鑫[1] 陈颖洁[1] 王芳[1] 刘婷[1] 宁尚义[2] 王玉 

机构地区：[1]山东大学第二医院,山东济南250033 [2]山东省医学科学院 [3]乳山市人民医院

出　　处：《山东医药》2002年第16期12-13,共2页Shandong Medical Journal

摘　　要：应用ELISA法对 41例慢性特发性血小板减少性紫癜 (ITP)患者和 2 5例健康对照者进行血浆和 (或 )血清血小板相关抗体 (PAIgG)、抗心磷脂抗体 (ACAIgG)测定 ,并常规血小板计数。发现ITP患者治疗有效组治疗后血小板计数明显升高、PAIgG含量显著降低 ,治疗前较治疗后及对照组均有显著性差异 (P <0 .0 1 ) ,且血小板计数与PAIgG之间呈显著性负相关 (r =- 0 .738,P <0 .0 0 1 )。而治疗无效组血小板计数、PAIgG均无明显变化。ACAIgG治疗前后无明显变化 ,且未发现与血小板及PAIgG相关。PAIgG、ACAIgG含量增高提示ITP患者针对血小板磷脂及其他糖类蛋白等不同抗原产生了自身免疫反应 。Blood platelet count(BPC),platelet associated antibodies(PAIgG) and anticardiolipin antibodies(ACAIgG) were measured by ELISA in 41 patients with idiopathic thrombocytpenic purpura(ITP) and 25 normal people as control group.Results showed that BPC was inecreased remarkably and PAIgG were decreased significantly in ITP patients than that in controls(P<0.01). After treated with immune suppressive,BPC and PAIgG turnned to normal level,but ACAIgG did not.There was a negtive relationship between BPC and PAIgG(r=-0.738,P<0.001),neither BPC nor PAIgG correlated to ACAIgG.The author concluded that autoimmune function played an important role in the pathogenesis of ITP.

关 键 词：慢性特发性血小板减少性紫癜 血小板相关抗体 抗心磷脂抗体 ITP 血小板计数 

分 类 号：R554.6[医药卫生—血液循环系统疾病]