海藻多糖铬络合物降糖作用的实验研究  

Experimental study on reducing serum glucose of seaweed polysaccharides-Cr^(3+) complex

作　　者：张磊[1] 曹毓[1] 彭龙玲[1] 温志坚[1] 杨亚斯[1] 

机构地区：[1]四川省中药研究所,成都610041

出　　处：《四川生理科学杂志》2002年第2期69-71,共3页Sichuan Journal of Physiological Sciences

摘　　要：目的 :研究海藻多糖铬络合物 (seaweedpolysaccharides Cr3 + complex ,SPC)的降糖作用。 方法 :以四氧嘧啶复制大、小鼠糖尿病模型 ,观察 60、1 5 0、3 0 0 μg·kg 1SPC预防、治疗给药不同时间的降糖作用。结果 :①60、1 5 0、3 0 0 μg·kg 1SPCop1 4d对正常小鼠血糖及糖耐受量无影响 (P >0 .0 5 )。② 60、1 5 0、3 0 0 μg·kg 1SPCop 1 4d对四氧嘧啶高血糖小鼠无明显治疗作用 (P >0 .0 5 )。③ 60、1 5 0、3 0 0 μg·kg 1SPC预防性op 1 4d能显著抑制四氧嘧啶所致小鼠、大鼠血糖的升高 (P <0 .0 5 )。结论 :SPC预防性给药各剂量组均能显著抑制四氧嘧啶所致大、小鼠血糖升高 ,提示其具有预防四氧嘧啶引起的血糖升高作用 ,对预防血糖的升高有重要作用。故有必要对海藻多糖铬络合物进一步深入研究 ,作出更全面的评价 。Objective: To observe the effect of seaweed polysarcharides Cr 3+ complex(SPC) on reducing the serum glucose. Methods: 60?150?300μg·kg 1 SPC was given as the prevention or treatment respectively, to observe their effects on reducing serum glucose in rats and mice with Alloxan-induced diabetic hyperglucomic. Results: ①SPC with 60?150?300μg·kg 1 dosages was not effective on normal mice serum glucose after ig14d,(P>0.05); SPC didn't reduce the peak value of serum glucose after glucose was given to mice(P>0.05).②SPC with 60?150?300μg·kg 1 dosages, as the treatment ig14d ,didn't reduce significantly serum glucose on mice(P>0.05).③SPC with 60?150?300μg·kg 1 dosages, as the preventive ig 14d, could reduce serum glucose on mice and rat respectively(P<0.05). Conclusion: SPC can significantly check the Alloxan induced hyperglucomic as the preventive.

关 键 词：海藻多糖铬络合物 降糖作用 实验研究 

分 类 号：R285.5[医药卫生—中药学]