双嘧达莫缓释微丸的研制及其体外释放特性  

Studies on preparation and in vitro release properties of sustained release pellets of dipyridamole

作　　者：王文刚[1] 崔光华[2] 王睿[1] 周筱青[1] 

机构地区：[1]中国人民解放军总医院临床药理药学研究室,北京100853 [2]军事医学科学院毒物药物研究所,北京100850

出　　处：《中国医院药学杂志》2002年第9期528-531,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的 :制备双嘧达莫 pH非依赖型缓释微丸 ,使药物释放不受胃肠道pH值变化及个体差异的影响。 方法 :采用固体分散技术 ,将药物与联合载体 (EudragitL、EC和PEG 60 0 0 )的混和有机液喷包于微晶纤维素 (MCC)空白丸芯上形成膜衣骨架型共沉淀物结构 ,以正交设计进行处方优化 ,考察不同pH条件下缓释微丸的释放特性。结果 :缓释微丸的体外药物释放呈pH非依赖型释放特征 ,符合一级动力学方程。结论 :具有溶解度pH依赖性的药物 ,以固体分散技术处理 ,通过不同性质载体的调节作用 ,可以制成pH非依赖型的缓释制剂。OBJECTIVE To prepare pH independent sustained release pellets of dipyridamole (DIP),the drug release not being influenced by pH of the gastrointestinal tract and by individual difference.METHODS Using solid dispersion methods,sustained release coevaperates(coating matrix) were prepared by spraying organic solution of DIP mixed carrier consist of Eudragit L、PEG6000 and EC blends onto MCC pellets.The orthogonal design method was used to optimize the formulation, and the in vitro release properties were studied. RESULTS The release of DIP from the pellets was pH independent and the dissolution profiles of it followed the first grade model kinetics. CONCLUSIONS By using solid dispersion methods and carriers exhibiting different properties, drugs of pH dependent in solubility could be used for making pH independent sustained release preparations.

关 键 词：双嘧达莫 缓释微丸 pH非依赖型释放 抗心绞痛药 

分 类 号：R972[医药卫生—药品] R944.9[医药卫生—药学]