脑脉舒宁对小鼠急性脑缺血保护作用的实验研究  

Protective Effete of Naomaishuning (NMS) on the Experimental Cerebral in Mice

作　　者：王淑英[1] 李艳[1] 张晓辉[2] 王建刚[1] 路西明[1] 

机构地区：[1]河南洛阳医学高等专科学校,洛阳471003 [2]河南省南阳市中心医院

出　　处：《中国中医药信息杂志》2002年第9期28-29,共2页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：河南省科技攻关项目(№.981170624)

摘　　要：目的:观察脑脉舒宁(NMS)对小鼠脑缺血损伤的保护作用。方法:采用小鼠双侧颈总动脉和迷走神经结扎法制作脑缺血模型并观察NMS对其的影响。结果:急性脑缺血时脑内丙二醛(MDA)、一氧化氮(NO)明显增加(P<0.05),超氧化物歧化酶(SOD)减少,而NMS可明显增加SOD,降低MDA,NO(P<0.05)。结论:NMS对小鼠急性脑缺血具有一定的保护作用。Objective: To observe the protective effects of NMS on cerebral ischemia reperfusion injury. Methods: The method of ligating both common carotid arteries and vagus nerves was used to make acute cerebral ischemia reperfusion injury in mice. Results: NMS increased notably brain SOD content, and at the same time decreased brain MDA and NO content on the cerebral ischemia (P<0.05). Conclusion: NMS may have protective effect on the cerebral ischemia injury in mice.

关 键 词：脑脉舒宁 小鼠 急性脑缺血 保护作用 实验研究 

分 类 号：R285.5[医药卫生—中药学] R277.733.1[医药卫生—中医学]