血清维生素D代谢产物水平与肾脏疾病的关系  

THE RELATIONSHIP BETWEEN SERUM LEVELS OF VITAMIN D METABOLITES AND RENAL DISEASE

作　　者：薛延[1] 李文菁[1] 祝恕德[2] 魏琴娥[2] 王丹琪[2] 杨守礼[3] 胡明[3] 李贵[4] 阎田玉[4] 

机构地区：[1]北京积水潭医院生化研究室 [2]北京积水潭医院内科 [3]中日友好医院同位素研究室 [4]北京友谊医院儿科

出　　处：《中华内分泌代谢杂志》1991年第2期84-86,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：用竞争性蛋白结合法和放射受体法观察了46例肾脏病患者血清维生素D代谢产物的变化。结果表明,各类肾脏病患者血清25-羟维生素D_3的含量均低于正常对照组,平均下降了41.2％(P<0.01),以尿毒症患者最低,表明肾脏病患者维生素D的营养状态是低下的。尿毒症和肾病综合征患者,血清1,25-二羟维生素D_3[1,25(OH)_2D_3]亦明显下降,分别比对照组降低了33.5％和42.4％(P<0.05),而慢性肾功能不全患者血清1,25(OH)_2D_3与肾功能不全的程度呈负相关。作者还对肾脏疾病维生素D代谢产物水平降低的机理进行了讨论。Alterations of serum vitamin D metabolites were observed by competitive protein-binding assay and radioreceptor assay in 46 patients with renal disease inckding chronic renal failure (CRF), nephrotic syndrcme (NS) and nephritis. The results indicated that serum 25-hydroxy-vitamin D (25-OHD) level decreased 41.2% as compared with the control group (P<0.01) and the lowest was found in uremic patients. It showed that vitamin D level is low in renal disease. Meanwhile serum 1,25-dihydroxy-vitamin D [1,25(OH)2D3] levels in uremia and NS patients decreased 33.5^ and 42.2% respectively (P<0.05) as compared with control group; serum l,.25(OH)2D3levels in CRF patients were negatively correlated with the severity of renal failure. The mechanism of low vitamin D metabolites in renal disease was discussed.

关 键 词：维生素D 代谢产物 肾脏疾病 

分 类 号：R692[医药卫生—泌尿科学]