肺炎衣原体与呼吸系统感染性疾病的关系  

Study on the relationship between chlamydia pneumoniae and infectious diseases of respiratory system

作　　者：吴向辉[1] 操乐杰[2] 王玮[1] 

机构地区：[1]安徽省立医院中心实验室,安徽合肥230001 [2]安徽省立医院呼吸内科,安徽合肥230001

出　　处：《疾病控制杂志》2002年第3期209-211,共3页Chinese Journal of Disease Control and Prevention

摘　　要：目的　探讨肺炎衣原体 (chlam ydia pneum oniae,Cpn)与呼吸系统感染性疾病的关系。方法　采用免疫荧光技术 ,对 10 4例呼吸系统感染性疾病和 40名正常人的血清进行了 Cpn特异性Ig G、Ig A、Ig M抗体的检测。结果　 Cpn Ig G抗体的阳性率患者组与对照组之间差异无显著性 (P>0 .0 5 ) ;慢性阻塞性肺疾病 (COPD)、慢性支气管炎患者 Cpn Ig A抗体的阳性率高于对照组 (P <0 .0 1) ;患者组 Cpn Ig G抗体几何平均滴度 (GMT)明显高于对照组 (P <0 .0 5 )。结论　 Cpn特异性抗体的检测有助于呼吸系统急、慢性 Cpn感染的诊断 ;持续高滴度的 Cpn Ig G或 Ig A抗体可作为慢性 Cpn感染的重要指标。Objective To find out the relationship between chlamydia pneumoniae and infectious diseases of respiratory system. Methods Chlamydia pneumoniae-specific serum IgG?IgA?IgM antibodies were measured by indirect immunofluorescence test in 104 patients with infectious diseases of respiratory system and in 40 controls. Results Significant deference of the positive rate of specific IgG antibodies between observation group and control group was not founded ( P >0.05). Significant deference of the positive rate of specific IgA antibodies between patients with COPD, chronic bronchitis and control group was founded ( P <0.01). Significant deference of the geometric mean titers (GMT) of Cpn-specific IgG antibody between observation group and control group was founded ( P <0.05). Conclusions Cpn-specific antibody will help diagnosis acute or chronic infectious diseases of respiratory system. Persistent high titer Cpn-specific IgG or IgA antibodies may be considered as an important marker of chronic Chlamydia pneumoniae infection.

关 键 词：免疫荧光技术 肺炎衣原体 呼吸系统 感染性疾病 

分 类 号：R374[医药卫生—病原生物学] R56[医药卫生—基础医学]