组织工程研究与开发进展  

ADVANCES IN RESEARCH AND DEVELOPMENT OF TISSUE ENGINEERING

作　　者：姚康德[1] 宋雪峰[1] 刘文广[1] 曹德勇[1] 陈亦平[1] 尹玉姬[1] 

机构地区：[1]天津大学高分子材料研究所,天津300072

出　　处：《中国修复重建外科杂志》2002年第5期325-328,共4页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家基础研究发展规划资助项目 (973)(G1 9990 5430 5);国家自然科学基金资助项目 (599730 1 4 )~~

摘　　要：目的　从材料科学角度出发 ,探讨组织工程修复和重建组织缺损的方法 :如骨髓基质干细胞 (MSCs)、生长因子、基因治疗及组织工程等。方法　重点查阅近期有关组织工程发展动向的文献 ,介绍组织工程技术进展。结果　组织工程应解决分子支架的设计与制备、组织血管化和细胞在支架上进行体外动态培养问题。结论　生物材料在组织工程中发挥重要作用 ,它们能用作骨髓基质干细胞、生长因子释放载体。Objective From the point of view of material science, the methods of tissue repair and defect reconstruct were discussed, including mesenchymal stem cells (MSCs), growth factors, gene therapy and tissue engineered tissue. Methods The advances in tissue engineering technologies were introduced based on the recent literature.Results Tissue engineering should solve the design and preparation of molecular scaffold, tissue vascularization and dynamic culture of cell on the scaffolds in vitro. Conclusion Biomaterials play an important role in the tissue engineering. They can be used as the matrices of MSCs, the delivery carrier of growth factor, the culture scaffold of cell in bioreactors and delivery carrier of gene encoding growth factors.

关 键 词：组织工程 生物材料 骨髓基质干细胞 生长因子 基因治疗 

分 类 号：R318.08[医药卫生—生物医学工程]