成体干细胞的分化潜能及在修复重建中的应用前景  

PLURIPOTENTIAL OF HUMAN ADULT STEM CELLS AND ITS APPLICATION IN REPARATIVE AND RECONSTRUCTIVE SURGERY

作　　者：潘兴华[1] 韩毅冰[2] 郭坤元[1] 陈系古[2] 

机构地区：[1]第一军医大学珠江医院血液科,广州510282 [2]中山医科大学动物实验部

出　　处：《中国修复重建外科杂志》2002年第5期329-332,共4页Chinese Journal of Reparative and Reconstructive Surgery

摘　　要：目的　探讨成体干细胞 (AS细胞 )的分化潜能性及在临床修复重建中应用的可能。方法　检索医学和生物医学文献数据库中关于 AS细胞研究的相关报道 ,并对 AS细胞的最新研究进展作简要总结。结果　 AS细胞存在于成体的各种组织中 ,具有自我更新能力和分化潜能性 ;部分成体干细胞 ,如骨髓、皮肤、肝及脂肪等组织中的 AS细胞 ,具有多向分化潜能 ,可向无关组织类型的成熟细胞横向分化 ;AS细胞是组织更新与修复的起源细胞 ,且与肿瘤的发生和衰老密切相关。结论　 AS细胞具有多向分化潜能 。Objective To explore the pluripotential and possible clinical application of adult stem cells. Methods The original articles on adult stem cells were extensively reviewed and the recent advances were summed up. Results Adult stem cells were located at different tissues of human beings and had the pluripotentiality of self renewal and differentiation. Some adult stem cells , such as in marrow, nerve, muscle, fat, skin, liver. tissues, had the ability to differentiate into the unrelated cell type. Conclusion The pluripotential,ubiquitous distribution and plasticity of adult stem cells offered a new way in regeneration medicine, such as cell therapy and tissue engineering.

关 键 词：成体干细胞 分化潜能 修复重建 再生医学 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]